Department of Biology, Faculty of Sciences, Mohammed V University, Rabat, Morocco.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Semin Thromb Hemost. 2021 Jun;47(4):419-426. doi: 10.1055/s-0041-1726033. Epub 2021 Apr 13.
Platelets, as nonnucleated blood components, are classically recognized for their pivotal role in hemostasis. In recent years, however, accumulating evidence points to a nonhemostatic role for platelets, as active participants in the inflammatory and immune responses to microbial organisms in infectious diseases. This stems from the ability of activated platelets to secrete a plethora of immunomodulatory cytokines and chemokines, as well as directly interplaying with viral receptors. While much attention has been given to the role of the cytokine storm in the severity of the coronavirus disease 2019 (COVID-19), less is known about the contribution of platelets to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we give a brief overview on the platelet contribution to antiviral immunity and response during SARS-CoV-2 infection.
血小板作为无核血细胞成分，经典地被认为在止血中起关键作用。然而，近年来，越来越多的证据表明血小板在感染性疾病中作为微生物的炎症和免疫反应的积极参与者发挥着非止血作用。这源于激活的血小板能够分泌大量的免疫调节细胞因子和趋化因子，并直接与病毒受体相互作用。虽然人们对细胞因子风暴在 2019 年冠状病毒病（COVID-19）严重程度中的作用给予了极大关注，但对血小板在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染中的作用知之甚少。在这里，我们简要概述了血小板在 SARS-CoV-2 感染期间对抗病毒免疫和反应的贡献。
