Khare Parul, Sun Jingjing, Wang Lizhen, Tian Zhen, Zhang Chunye, Hu Yuhua, Xia Ronghui, Li Jiang
Department of Oral Pathology, Faculty of Dental Sciences, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Centre of Stomatology, China.
Indian J Pathol Microbiol. 2021 Apr-Jun;64(2):339-342. doi: 10.4103/IJPM.IJPM_423_20.
Soft tissue keratocysts (SKC) are extremely rare and show similar microscopic morphology to keratocystic odontogenic tumor. The aim was to investigate immunohistochemical (IHC) features and origin of SKCs developing in buccal mucosa and lateral facial deep region.
Expression of CK19, CK10/13, Ki67, Cyclin D1 and Osteopontin (OPN) of 9 SKCS were investigated using IHC. Forty different types of cysts in jaw/soft tissue were used as control. Follow-up was performed.
CK10/13 positivity occurred more frequently and intensely in SKC and intraosseous parakeratinized odontogenic keratocysts (COKC). However, OPN positivity was observed only in COKC.
This is the largest case series of SKCs; along with first attempt to investigate the expression of OPN on SKC. Given the microscopic and immunohistochemical features, we prefer the view that SKC is odontogenic origin but represents the soft tissue counterpart of COKC, since their expressions of OPN were extremely different.
软组织角化囊肿（SKC）极为罕见，其微观形态与牙源性角化囊性瘤相似。本研究旨在探讨发生于颊黏膜及面部深部外侧区域的SKC的免疫组化（IHC）特征及起源。
采用免疫组化方法检测9例SKC中细胞角蛋白19（CK19）、细胞角蛋白10/13（CK10/13）、Ki67、细胞周期蛋白D1（Cyclin D1）和骨桥蛋白（OPN）的表达情况。选取40种不同类型的颌骨/软组织囊肿作为对照。进行随访。
CK10/13阳性在SKC及骨内正角化型牙源性角化囊肿（COKC）中出现的频率更高且强度更大。然而，仅在COKC中观察到OPN阳性。
这是最大的SKC病例系列研究；同时也是首次尝试研究OPN在SKC中的表达情况。鉴于其微观和免疫组化特征，我们倾向于认为SKC起源于牙源性，但代表COKC的软组织对应物，因为它们的OPN表达差异极大。
