Ayyanar Pavithra, Begum Jasmina, Rout Subhashree, Mishra Pritinanda
Department of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India.
Indian J Pathol Microbiol. 2021 Apr-Jun;64(2):385-389. doi: 10.4103/IJPM.IJPM_41_20.
Mature cystic teratoma of the ovary (MCT) is rare in pre and postmenopausal age patients. Among various types of malignant transformation in MCT, adenocarcinoma is a rare subtype. Dual type tumors arising from ovarian MCT have been described in the literature very rarely. A 47-year-old postmenopausal female patient presented with abdominal mass for ten years. The radiological opinion was a dermoid cyst. Grossly, a 22 × 20 × 10 cm, unilocular cystic left ovarian mass with intact capsular surface and focal thickened wall measured 3.0 cm. Microscopically, it showed components of all three germ cell layers. In addition, features of colonic type adenocarcinoma and well-differentiated neuroendocrine tumor (carcinoid) were noted and confirmed by immunohistochemistry (IHC). We report this rare case of synchronous malignancy arising from an ovarian MCT with a clinicopathological review.
成熟性卵巢囊性畸胎瘤（MCT）在绝经前和绝经后患者中较为罕见。在MCT的各种恶性转化类型中，腺癌是一种罕见的亚型。文献中很少描述源自卵巢MCT的双类型肿瘤。一名47岁的绝经后女性患者因腹部肿块就诊，病史长达十年。影像学诊断为皮样囊肿。大体检查可见，左侧卵巢有一个22×20×10 cm的单房囊性肿块，包膜表面完整，局部壁厚3.0 cm。显微镜检查显示其具有所有三个胚层的成分。此外，还发现了结肠型腺癌和高分化神经内分泌肿瘤（类癌）的特征，并通过免疫组织化学（IHC）得以证实。我们通过临床病理回顾报告了这例源自卵巢MCT的罕见同步恶性肿瘤病例。
