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起源于卵巢成熟囊性畸胎瘤的胃肠道谱系混合性神经内分泌/非神经内分泌肿瘤（MiNEN）

Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma.

作者信息

Dasaraju Sandhyarani, Amin Khalid, Klein Molly E, Rivard Colleen, Mattson Jordan, Davidson Sarah, Khalifa Mahmoud A

机构信息

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, US.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Gynecol Oncol Rep. 2022 Nov 5;44:101099. doi: 10.1016/j.gore.2022.101099. eCollection 2022 Dec.

DOI:10.1016/j.gore.2022.101099
PMID:36388757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9663321/
Abstract

•Mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma is extremely rare.•It is important to differentiate the gastrointestinal-type adenocarcinoma arising along with neuroendocrine tumor from a primary mucinous adenocarcinoma of the ovary. SATB2 and CDX2 Immunohistochemical stains play important role in differentiate these two.•This case highlights the careful morphologic evaluation and extensive sampling is crucial to make this rare diagnosis.

摘要

•起源于卵巢成熟囊性畸胎瘤的胃肠道谱系混合性神经内分泌/非神经内分泌肿瘤（MiNEN）极为罕见。

•将伴随神经内分泌肿瘤出现的胃肠道型腺癌与卵巢原发性黏液腺癌区分开来很重要。SATB2和CDX2免疫组化染色在鉴别这两者中起重要作用。

•该病例强调了仔细的形态学评估和广泛取材对于做出这种罕见诊断至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/af7022cb2029/gr3h.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/67f06d39837e/gr2c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/83039d19d0db/gr2d.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/65dfc7a13f52/gr2a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/043653db4dfb/gr2b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/67f06d39837e/gr2c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/f382ea30f21a/gr3a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/f0473b263f10/gr3b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/afe36742fd3b/gr3c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/c651512dfcee/gr3d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/0a9f12a29d63/gr3e.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/af7022cb2029/gr3h.jpg

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本文引用的文献

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Endocr Pathol. 2022 Sep;33(3):400-410. doi: 10.1007/s12022-021-09689-8. Epub 2021 Aug 3.
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Synchronous colonic adenocarcinoma and well-differentiated neuroendocrine tumor arising in a mature cystic teratoma of ovary - rare presentation in a postmenopausal woman with literature review.卵巢成熟性囊性畸胎瘤中同步发生的结肠腺癌和高分化神经内分泌肿瘤——一名绝经后女性的罕见病例并文献复习
Indian J Pathol Microbiol. 2021 Apr-Jun;64(2):385-389. doi: 10.4103/IJPM.IJPM_41_20.
3
Mixed epithelial endocrine neoplasms of the colon and rectum - An evolution over time: A systematic review.
结肠和直肠混合性上皮内分泌肿瘤——随时间的演变：一项系统综述
World J Gastroenterol. 2020 Sep 14;26(34):5181-5206. doi: 10.3748/wjg.v26.i34.5181.
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Multiple malignant transformations of an ovarian mature cystic teratoma.卵巢成熟囊性畸胎瘤的多次恶性转化
Ecancermedicalscience. 2020 Feb 4;14:1009. doi: 10.3332/ecancer.2020.1009. eCollection 2020.
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Digestive System Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.消化系统混合性神经内分泌-非神经内分泌肿瘤。
Neuroendocrinology. 2017;105(4):412-425. doi: 10.1159/000475527. Epub 2017 Aug 12.
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SATB2 is a sensitive marker for lower gastrointestinal well-differentiated neuroendocrine tumors.SATB2是下消化道高分化神经内分泌肿瘤的敏感标志物。
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