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起源于卵巢成熟囊性畸胎瘤的胃肠道谱系混合性神经内分泌/非神经内分泌肿瘤(MiNEN)

Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma.

作者信息

Dasaraju Sandhyarani, Amin Khalid, Klein Molly E, Rivard Colleen, Mattson Jordan, Davidson Sarah, Khalifa Mahmoud A

机构信息

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, US.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.

出版信息

Gynecol Oncol Rep. 2022 Nov 5;44:101099. doi: 10.1016/j.gore.2022.101099. eCollection 2022 Dec.

Abstract

•Mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma is extremely rare.•It is important to differentiate the gastrointestinal-type adenocarcinoma arising along with neuroendocrine tumor from a primary mucinous adenocarcinoma of the ovary. SATB2 and CDX2 Immunohistochemical stains play important role in differentiate these two.•This case highlights the careful morphologic evaluation and extensive sampling is crucial to make this rare diagnosis.

摘要

•起源于卵巢成熟囊性畸胎瘤的胃肠道谱系混合性神经内分泌/非神经内分泌肿瘤(MiNEN)极为罕见。

•将伴随神经内分泌肿瘤出现的胃肠道型腺癌与卵巢原发性黏液腺癌区分开来很重要。SATB2和CDX2免疫组化染色在鉴别这两者中起重要作用。

•该病例强调了仔细的形态学评估和广泛取材对于做出这种罕见诊断至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9663321/8307da6a5b8c/gr1.jpg

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