King Abdulaziz University, Faculty of Dentistry, Department of Oral Biology, Jeddah, Saudi Arabia.
Niger J Clin Pract. 2021 Apr;24(4):457-463. doi: 10.4103/njcp.njcp_498_20.
The use of dental stem cells (DSCs) has emerged as a promising new approach for therapeutic purposes to treat dental and non-dental diseases. Thus, the aim of this systematic review was to compile all current information on the role and clinical applications of DSCs in modern regenerative medical therapy. PubMed and Google Scholar electronic databases were used to search the literature for relevant studies after applying specific inclusion and exclusion criteria. The search included articles that were published from 2009 to 2019. Several keywords were combined for the search: (1) "Clinical applications", (2) "Dental Stem Cell", and (3) "Medicine". Only the 17 studies that fulfilled both the inclusion and exclusion criteria were included in this systematic review. These studies investigated different aspects of DSCs, including cell types, clinical applications, and updates of their use in regenerative medicine. All 17 studies favored the use of different DSCS in regenerative medicine to treat diseases, such as bone defects, neural and skin injuries, Parkinson's disease, ischemia, and others. None of the studies were conducted on humans. This systematic review demonstrated the growing body of evidence supporting the role of DSCs in the field of modern generative medicine. The noninvasive methods of isolating these cells compared to those for isolating non-DSCs make them promising potential sources for the treatment of chronic and devastating diseases. However, more studies are needed to develop the proper guidelines for cases in which DSCs could be considered an accurate and reliable tool for modern regenerative medicine in clinical trials.
牙髓干细胞（Dental Stem Cells，DSCs）的应用作为一种有前途的新方法，可用于治疗牙齿和非牙齿疾病的治疗目的。因此，本系统评价的目的是综合所有关于 DSCs 在现代再生医学治疗中的作用和临床应用的最新信息。在应用特定的纳入和排除标准后，使用 PubMed 和 Google Scholar 电子数据库搜索相关研究。检索包括 2009 年至 2019 年发表的文章。为搜索使用了几个关键词：（1）“临床应用”，（2）“牙髓干细胞”，（3）“医学”。仅纳入了符合纳入和排除标准的 17 项研究。这些研究调查了 DSCs 的不同方面，包括细胞类型、临床应用以及它们在再生医学中的使用更新。所有 17 项研究都支持使用不同的 DSCs 治疗再生医学中的疾病，如骨缺损、神经和皮肤损伤、帕金森病、缺血等。没有一项研究是在人类身上进行的。本系统评价证明了越来越多的证据支持 DSCs 在现代再生医学领域的作用。与分离非 DSCs 相比，分离这些细胞的非侵入性方法使它们成为治疗慢性和破坏性疾病的有前途的潜在来源。然而，需要更多的研究来制定适当的指南，以便在临床试验中可以将 DSCs 视为现代再生医学的准确和可靠工具。
