Department of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples 80138, Italy.
World J Gastroenterol. 2021 Sep 14;27(34):5793-5795. doi: 10.3748/wjg.v27.i34.5793.
The relationship between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) has gained considerable scientific interest in adults over the past few years. However, this association has recently emerged in children. Several published studies have suggested a role for NAFLD as a risk factor for CKD from the earliest age, with a potential influence of the major NAFLD risk polymorphisms, resulting in an increased risk of both cardiovascular and metabolic diseases. In view of the progressive course and increased cardiometabolic risk closely related to NAFLD and CKD, we focused on the link between these diseases in childhood.
非酒精性脂肪性肝病 (NAFLD) 和慢性肾脏病 (CKD) 之间的关系在过去几年中引起了成人科学界的极大关注。然而，这种关联最近也出现在儿童中。一些已发表的研究表明，NAFLD 是导致儿童 CKD 的一个危险因素，主要的 NAFLD 风险多态性可能会导致心血管和代谢疾病的风险增加。鉴于与 NAFLD 和 CKD 密切相关的疾病进展过程和增加的心血管代谢风险，我们专注于儿童时期这些疾病之间的联系。
