Lam K, Astrahan M, Langholz B, Jepson J, Cohen D, Luxton G, Petrovich Z
Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033.
Int J Hyperthermia. 1988 May-Jun;4(3):259-66. doi: 10.3109/02656738809051102.
Between 1984 and 1986, 31 sites in 27 patients with biopsy proven tumours were treated with a combination of interstitial microwave hyperthermia (HT) and iridium 192 implants (RT). The 31 sites treated included fifteen (48 per cent) head and neck, six (20 per cent) breast, four (13 per cent) vagina and cervix, and six (20 per cent) others. All patients had prior surgery, RT, or chemotherapy. Of the 31 sites treated, 19 (61 per cent) had complete response (CR) with no recurrence in the volume treated. Additionally, eight patients remained free of tumour from 3 to 24 months. Partial response (PR) was seen in 11 (36 per cent) sites while one (3 per cent) had lesser degree tumour regression. Tumour control rate correlated well with the dose of radiation, p = 0.02, and tumour volume, p = 0.02, but not with thermal dose. Treatment complications of significance occurred in one (3 per cent) site, which developed soft tissue necrosis. This study again has demonstrated the effectiveness of RT-HT combination in treatment of recurrent tumours.
1984年至1986年间，对27例经活检证实患有肿瘤的患者的31个部位进行了间质微波热疗（HT）和铱192植入（RT）联合治疗。所治疗的31个部位包括15个（48%）头颈部、6个（20%）乳房、4个（13%）阴道和子宫颈以及6个（20%）其他部位。所有患者均曾接受过手术、放疗或化疗。在接受治疗的31个部位中，19个（61%）获得完全缓解（CR），治疗区域无复发。此外，8例患者在3至24个月内无肿瘤。11个（36%）部位出现部分缓解（PR），1个（3%）部位肿瘤消退程度较小。肿瘤控制率与辐射剂量（p = 0.02）和肿瘤体积（p = 0.02）密切相关，但与热剂量无关。有1个（3%）部位出现了严重的治疗并发症，发生了软组织坏死。这项研究再次证明了放疗-热疗联合治疗复发性肿瘤的有效性。
