高选择性地从 -二氟烯烃与亚硫酸钠制备 α-氟-β-芳基烯基砜。
Highly -Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from -Difluoroalkenes with Sodium Sulfinates.
机构信息
State Key Laboratory of Microbial Technology and Marine Biotechnology Research Center, Shandong University, 72 Binhai Road, Qingdao 266237, Shandong, P. R. China.
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, 168 Wenhai Road, Qingdao 266237, Shandong, P. R. China.
出版信息
J Org Chem. 2021 May 7;86(9):6983-6993. doi: 10.1021/acs.joc.1c00490. Epub 2021 Apr 14.
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
本文描述了在无过渡金属和碱条件下α-氟代-β-芳基烯基砜的直接合成方法，该方法具有广泛的官能团兼容性和高立体选择性。特别是，该策略也可用于复杂天然产物和药物的后期修饰。
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