Mayayo-Peralta Isabel, Zwart Wilbert, Prekovic Stefan
Division of Oncogenomics, Oncode Institute, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Endocr Relat Cancer. 2021 May 11;28(6):R157-R171. doi: 10.1530/ERC-20-0489.
Glucocorticoid receptor (GR) is a key homeostatic regulator involved in governing immune response, neuro-integration, metabolism and lung function. In conjunction with its pivotal role in human biology, GR action is critically linked to the pathology of various disease types, including cancer. While pharmacological activation of GR has been used for the treatment of various liquid cancers, its role in solid cancers is less clearly defined and seems to be cancer-type dependent. This review focuses on the molecular aspects of GR biology, spanning the structural and functional basis of response to glucocorticoids, as well as how this transcription factor operates in cancer, including the implications in disease development, progression and drug resistance.
糖皮质激素受体（GR）是一种关键的稳态调节因子，参与免疫反应、神经整合、代谢和肺功能的调控。鉴于其在人类生物学中的关键作用，GR的作用与包括癌症在内的多种疾病类型的病理学密切相关。虽然GR的药理激活已用于治疗各种液体癌症，但其在实体癌中的作用尚不清楚，似乎取决于癌症类型。本综述聚焦于GR生物学的分子层面，涵盖对糖皮质激素反应的结构和功能基础，以及这种转录因子在癌症中的作用机制，包括对疾病发生、发展和耐药性的影响。
