Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Brain Res. 2021 Aug 1;1764:147477. doi: 10.1016/j.brainres.2021.147477. Epub 2021 Apr 20.
Rapid eye movement (REM) sleep behavior disorder (RBD) is one of the common nonmotor symptoms of Parkinson's disease (PD), characterized by frequently occurring REM sleep without muscle atonia. Our aim was to explore dynamic network connection changes in PD patients with RBD.
On the basis of RBD screening questionnaire (RBDSQ), 126 PD patients were classified into those with probable RBD symptoms (PD-pRBD) and without probable RBD (PD-npRBD). We applied independent component analysis, sliding window approach and k-means clustering methods to clarify dynamic functional connectivity alterations.
In contrast to PD-npRBD, PD-pRBD patients were liable to engage in a brain pattern mainly marked by weaker positive couplings between visual network (VIS) and default mode network (DMN), DMN and basal ganglia network (BG), and within DMN (State IV). In addition, we discovered that both PD patients with or without pRBD had shorter dwell time and fewer occurrences in State III, characterized by positive correlations between VIS and DMN, BG and DMN, and positive within-network coupling of sensorimotor network (SMN), relative to healthy controls.
Our study suggested that the weaker positive couplings between VIS and DMN, DMN and BG, and within DMN in State IV could be involved in the pathogenesis of PD patients with probable RBD on an overall level.
快速眼动（REM）睡眠行为障碍（RBD）是帕金森病（PD）的常见非运动症状之一，其特征是 REM 睡眠频繁发生而肌肉无张力。我们的目的是探索 RBD 帕金森病患者的动态网络连接变化。
基于 RBD 筛查问卷（RBDSQ），将 126 名 PD 患者分为有 RBD 症状（PD-pRBD）和无 RBD 症状（PD-npRBD）的患者。我们应用独立成分分析、滑动窗口方法和 k-均值聚类方法来阐明动态功能连接变化。
与 PD-npRBD 相比，PD-pRBD 患者更容易出现以视觉网络（VIS）和默认模式网络（DMN）、DMN 和基底节网络（BG）之间以及 DMN 内（状态 IV）较弱正耦合为特征的脑模式。此外，我们发现，无论是否存在 pRBD，PD 患者的状态 III 持续时间更短，发生次数更少，其特征是 VIS 与 DMN、BG 与 DMN 之间以及感觉运动网络（SMN）内的正相关，与健康对照组相比。
我们的研究表明，状态 IV 中 VIS 与 DMN、DMN 与 BG 以及 DMN 内较弱的正耦合可能与总体上有 RBD 症状的 PD 患者的发病机制有关。
