Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Department of Radiology, Clinical Medical College, Yangzhou University, Yangzhou, China.
J Cereb Blood Flow Metab. 2022 Sep;42(9):1719-1731. doi: 10.1177/0271678X221098503. Epub 2022 Apr 26.
Pathological process in Parkinson's disease (PD) is accompanied with functional and metabolic alterations. The time-varying properties of functional coherence and their coupling to regional perfusion are still rarely elucidated. To investigate early disruption of dynamic regional homogeneity (dReho) and neurovascular coupling in cognitively normal PD patients, dynamic neuronal synchronization and regional perfusion were measured using dReho and cerebral blood flow (CBF), respectively. Neurovascular coupling was assessed by CBF-ReHo correlation coefficient and CBF/ReHo ratio. Multivariate pattern analysis was conducted for the differentiating ability of each feature. Relative to healthy controls (HC) subjects, PD patients demonstrated increased dReho in middle temporal gyrus (MTG), rectus gyrus, middle occipital gyrus, and precuneus, whereas reduced dReho in putamen and supplementary motor area (SMA); while higher CBF/dReho ratio was located in putamen, SMA, paracentral lobule, and postcentral gyrus, whereas lower CBF/dReho ratio in superior temporal gyrus, MTG, precuneus, and angular gyrus (AG). Global and regional CBF-Reho decoupling were both observed in PD groups. The CBF/Reho ratio features achieved more powerful classification performance than other features. From the view of dynamic neural synchronization and neurovascular coupling, this study reinforced the insights into neural basis underlying PD and the potential role in the disease diagnosis and differentiation.
帕金森病 (PD) 的病理过程伴随着功能和代谢改变。功能相干性的时变特性及其与区域灌注的耦合仍很少被阐明。为了研究认知正常 PD 患者中动态局部一致性 (dReho) 和神经血管耦合的早期破坏，使用 dReho 和脑血流 (CBF) 分别测量动态神经元同步和区域灌注。通过 CBF-ReHo 相关系数和 CBF/ReHo 比值评估神经血管耦合。进行多变量模式分析以评估每个特征的区分能力。与健康对照组 (HC) 相比，PD 患者的颞中回 (MTG)、直回、中枕叶和楔前叶的 dReho 增加，而壳核和辅助运动区 (SMA) 的 dReho 减少；而壳核、SMA、旁中央小叶和中央后回的 CBF/dReho 比值较高，而颞上回、MTG、楔前叶和角回的 CBF/dReho 比值较低。PD 组均观察到全局和局部 CBF-ReHo 解耦。CBF/ReHo 比值特征比其他特征具有更强的分类性能。从动态神经同步和神经血管耦合的角度来看，本研究加强了对 PD 神经基础的深入了解，并为疾病诊断和鉴别提供了潜在的作用。
