Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, Mental Illness Research, Education, and Clinical Center (MIRECC), La Jolla, CA, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
J Psychiatr Res. 2021 Jun;138:139-145. doi: 10.1016/j.jpsychires.2021.04.007. Epub 2021 Apr 3.
Peripheral levels of pro-inflammatory biomarkers have been shown to be altered in schizophrenia (SZ) and associated with cognitive impairments, but their relevance to specific cognitive domains remains unclear.
Plasma levels of cytokines, chemokines, and vascular biomarkers were quantified and compared between SZ and healthy comparison (HC) groups. Cognition was assessed using the Delis-Kaplan Executive Function System Trail Making (TM) and Color Word Interference (CWI) tests. Linear regression analyses examined differential relationships of inflammatory biomarkers with executive function between groups.
Plasma levels of TNFα, ICAM1, and MCP1 were higher in individuals with SZ compared to HCs. Higher level of MCP1 was associated with increased CWI Inhibition Switching Errors in SZ but not HCs.
Like other studies, we found evidence for increased peripheral inflammation in SZ. We also showed that SZ with particularly high MCP1 levels had poor cognitive flexibility. Interventions to reduce chemokine elevations might prove beneficial for cognitive performance.
研究表明，精神分裂症（SZ）患者外周血中促炎生物标志物水平发生改变，并与认知障碍相关，但它们与特定认知领域的关系尚不清楚。
定量检测并比较 SZ 患者和健康对照组（HC）外周血中细胞因子、趋化因子和血管生物标志物的水平。采用 Delis-Kaplan 执行功能系统的连线测试（TM）和颜色词干扰（CWI）测试评估认知功能。线性回归分析考察了炎症生物标志物与两组人群执行功能之间的差异关系。
与 HC 相比，SZ 患者的 TNFα、ICAM1 和 MCP1 血浆水平升高。较高的 MCP1 水平与 SZ 患者的 CWI 抑制转换错误增加相关，但在 HC 中则无此相关性。
与其他研究一样，我们发现 SZ 患者外周血中存在炎症反应增强的证据。我们还表明，MCP1 水平特别高的 SZ 患者认知灵活性较差。降低趋化因子水平的干预措施可能对认知功能有益。
