Key Laboratory of Shaanxi Administration of Traditional Chinese, Medicine for TCM Compatibility, State Key Laboratory of Research and Development of Characteristic, Qin Medicine Resources (Cultivation), Shaanxi Collaborative Innovation Center of Chinese Medicinal, Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, 712046, P. R. China.
Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P. R. China.
Am J Chin Med. 2021;49(4):785-803. doi: 10.1142/S0192415X21500373. Epub 2021 Apr 9.
The coronavirus disease 2019 (COVID-19) spreads and rages around the world and threatens human life. It is disappointing that there are no specific drugs until now. The combination of traditional Chinese medicine (TCM) and western medication seems to be the current more effective treatment strategy for COVID-19 patients in China. In this review, we mainly discussed the relationship between COVID-19 and gut microbiota (GM), as well as the possible impact of TCM combined with western medication on GM in the treatment of COVID-19 patients, aiming to provide references for the possible role of GM in TCM against COVID-19. The available data suggest that GM dysbiosis did occur in COVID-19 patients, and the intervention of GM could ameliorate the clinical condition of COVID-19 patients. In addition, TCMs (e.g., Jinhua Qinggan granule, Lianhua Qingwen capsule, Qingfei Paidu decoction, Shufeng Jiedu capsule, Qingjin Jianghuo decoction, Toujie Quwen granules, and MaxingShigan) have been proven to be safe and effective for the treatment of COVID-19 in Chinese clinic. Among them, , , , ,, and are common herbs and have a certain regulation on GM, immunity, and angiotensin converting enzyme 2 (ACE2). Notably, Qingfei Paidu decoction and MaxingShigan have been demonstrated to modulate GM. Finally, the hypothesis of GM-mediated TCM treatment of COVID-19 is proposed, and more clinical trials and basic experiments need to be initiated to confirm this hypothesis.
新型冠状病毒病（COVID-19）在全球范围内传播和肆虐，威胁着人类的生命。令人失望的是，到目前为止还没有特定的药物。在中国，中药（TCM）与西药联合似乎是目前治疗 COVID-19 患者更有效的治疗策略。在这篇综述中，我们主要讨论了 COVID-19 与肠道微生物群（GM）的关系，以及 TCM 与西药联合治疗 COVID-19 患者对 GM 的可能影响，旨在为 GM 在 TCM 防治 COVID-19 中的可能作用提供参考。现有数据表明，COVID-19 患者确实存在 GM 失调，GM 的干预可以改善 COVID-19 患者的临床状况。此外，中药（如金花清感颗粒、连花清瘟胶囊、清肺排毒汤、疏风解毒胶囊、清金降火汤、透解祛瘟颗粒和麻杏石甘汤）已被证明在中国临床治疗 COVID-19 是安全有效的。其中，、、、、、和 是常用草药，对 GM、免疫和血管紧张素转换酶 2（ACE2）有一定的调节作用。值得注意的是，清肺排毒汤和麻杏石甘汤已被证明可以调节 GM。最后，提出了 GM 介导的 TCM 治疗 COVID-19 的假设，并需要开展更多的临床试验和基础实验来验证这一假设。
