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High-Yield Expression and Purification of Recombinant Influenza Virus Proteins from Stably-Transfected Mammalian Cell Lines.从稳定转染的哺乳动物细胞系中高效表达和纯化重组流感病毒蛋白
Vaccines (Basel). 2020 Aug 21;8(3):462. doi: 10.3390/vaccines8030462.
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Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection.携带2009年大流行病毒基因、易使人感染的常见欧亚禽源样H1N1猪流感病毒。
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17204-17210. doi: 10.1073/pnas.1921186117. Epub 2020 Jun 29.
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An Influenza Virus Hemagglutinin Computationally Optimized Broadly Reactive Antigen Elicits Antibodies Endowed with Group 1 Heterosubtypic Breadth against Swine Influenza Viruses.一种经计算优化的具有广泛反应性的流感病毒血凝素抗原可诱导产生对甲型流感病毒1组具有异源亚型广度的抗体，对猪流感病毒有效。
J Virol. 2020 Mar 31;94(8). doi: 10.1128/JVI.02061-19.
4
A Computationally Optimized Broadly Reactive Antigen Subtype-Specific Influenza Vaccine Strategy Elicits Unique Potent Broadly Neutralizing Antibodies against Hemagglutinin.一种经过计算优化的具有广泛反应性的抗原亚型特异性流感疫苗策略，可诱导针对血凝素的独特、强效的广谱中和抗体。
J Immunol. 2020 Jan 15;204(2):375-385. doi: 10.4049/jimmunol.1900379. Epub 2019 Dec 6.
5
Elicitation of Broadly Protective Antibodies following Infection with Influenza Viruses Expressing H1N1 Computationally Optimized Broadly Reactive Hemagglutinin Antigens.感染表达经计算优化的广泛反应性血凝素抗原的H1N1流感病毒后诱导产生广泛保护性抗体
Immunohorizons. 2018 Aug 27;2(7):226-237. doi: 10.4049/immunohorizons.1800044.
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A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases.通用流感疫苗：美国国立过敏和传染病研究所的战略计划。
J Infect Dis. 2018 Jul 2;218(3):347-354. doi: 10.1093/infdis/jiy103.
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Towards a universal influenza vaccine: different approaches for one goal.迈向通用流感疫苗：殊途同归。
Virol J. 2018 Jan 19;15(1):17. doi: 10.1186/s12985-017-0918-y.
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Computationally Optimized Broadly Reactive Hemagglutinin Elicits Hemagglutination Inhibition Antibodies against a Panel of H3N2 Influenza Virus Cocirculating Variants.通过计算优化的广泛反应性血凝素可引发针对一组H3N2流感病毒共同流行变体的血凝抑制抗体。
J Virol. 2017 Nov 30;91(24). doi: 10.1128/JVI.01581-17. Print 2017 Dec 15.
9
Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses.针对H1N1流感病毒的计算优化广谱反应性血凝素疫苗的设计与特性分析
J Virol. 2016 Apr 14;90(9):4720-4734. doi: 10.1128/JVI.03152-15. Print 2016 May.
10
A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets.一种基于计算优化的广谱反应性抗原（COBRA）的 H5N1 VLP 疫苗在小鼠和雪貂中引发了广谱反应性抗体。
Vaccine. 2011 Apr 5;29(16):3043-54. doi: 10.1016/j.vaccine.2011.01.100. Epub 2011 Feb 12.

An H1N1 Computationally Optimized Broadly Reactive Antigen Elicits a Neutralizing Antibody Response against an Emerging Human-Infecting Eurasian Avian-Like Swine Influenza Virus.

作者信息

Sautto Giuseppe A, Ecker Jeffrey W, Ross Ted M

机构信息

Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA.

Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA.

出版信息

J Virol. 2021 Jun 10;95(13):e0242120. doi: 10.1128/JVI.02421-20.

DOI:10.1128/JVI.02421-20
PMID:33853960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8316128/
Abstract
摘要