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An Influenza Virus Hemagglutinin Computationally Optimized Broadly Reactive Antigen Elicits Antibodies Endowed with Group 1 Heterosubtypic Breadth against Swine Influenza Viruses.

作者信息

Skarlupka Amanda L, Reneer Z Beau, Abreu Rodrigo B, Ross Ted M, Sautto Giuseppe A

机构信息

Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA.

Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA.

出版信息

J Virol. 2020 Mar 31;94(8). doi: 10.1128/JVI.02061-19.

DOI:10.1128/JVI.02061-19
PMID:31996430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7108850/
Abstract
摘要

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J Immunol. 2020 Jan 15;204(2):375-385. doi: 10.4049/jimmunol.1900379. Epub 2019 Dec 6.
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Hemagglutinin consensus-based prophylactic approaches to overcome influenza virus diversity.基于血凝素共识的预防方法以克服流感病毒多样性。
Vet Ital. 2019 Sep 30;55(3):195-201. doi: 10.12834/VetIt.1944.10352.1.
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Computationally optimized broadly reactive vaccine based upon swine H1N1 influenza hemagglutinin sequences protects against both swine and human isolated viruses.基于猪 H1N1 流感血凝素序列的计算优化广谱反应性疫苗可预防猪源性和人源性分离病毒。
Hum Vaccin Immunother. 2019;15(9):2013-2029. doi: 10.1080/21645515.2019.1653743.
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Next Generation Vaccines for Infectious Diseases.传染病的新一代疫苗
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Towards a universal influenza vaccine: different approaches for one goal.迈向通用流感疫苗：殊途同归。
Virol J. 2018 Jan 19;15(1):17. doi: 10.1186/s12985-017-0918-y.
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Elicitation of Protective Antibodies against a Broad Panel of H1N1 Viruses in Ferrets Preimmune to Historical H1N1 Influenza Viruses.在对历史H1N1流感病毒具有免疫前状态的雪貂中诱导针对多种H1N1病毒的保护性抗体。
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