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抗中性粒细胞胞浆抗体相关性肾小球肾炎与恶性肿瘤:一例同时诊断为肾衰竭和肺癌的患者

Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis and Malignancy: A Case of a Patient Diagnosed with Renal Failure and Pulmonary Carcinoma Concurrently.

作者信息

Asakura Maki, Akimoto Tetsu, Ohara Ken, Masuda Takahiro, Ono Yuko, Saito Osamu, Nagata Daisuke

机构信息

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.

Department of Chronic Kidney Disease Pathophysiology, Jichi Medical University, Tochigi.

出版信息

Clin Med Insights Case Rep. 2021 Mar 28;14:11795476211004604. doi: 10.1177/11795476211004604. eCollection 2021.

DOI:10.1177/11795476211004604
PMID:33854397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8010803/
Abstract

A 70-year-old man presented with proteinuria, microscopic hematuria, and an increased level of serum creatinine. A systemic workup revealed that the patient had bronchogenic carcinoma and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis concurrently. Despite the increase in the cumulative number of publications on paraneoplastic glomerulopathies, an awareness of the link between cancer and ANCA-associated glomerulonephritis is lacking. We strongly recommend the accumulation of more cases similar to our own, thereby allowing us to clarify the management strategies as well as the nature of this disease condition more precisely.

摘要

一名70岁男性出现蛋白尿、镜下血尿和血清肌酐水平升高。全面检查发现该患者同时患有支气管源性癌和抗中性粒细胞胞浆抗体(ANCA)相关肾小球肾炎。尽管关于副肿瘤性肾小球病的累计出版物数量有所增加,但仍缺乏对癌症与ANCA相关肾小球肾炎之间联系的认识。我们强烈建议积累更多与我们病例类似的病例,从而使我们能够更精确地阐明这种疾病状况的管理策略及其本质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dc/8010803/af688ac241db/10.1177_11795476211004604-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dc/8010803/74157321eed2/10.1177_11795476211004604-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dc/8010803/af688ac241db/10.1177_11795476211004604-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dc/8010803/74157321eed2/10.1177_11795476211004604-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9dc/8010803/af688ac241db/10.1177_11795476211004604-fig2.jpg

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Antibodies (Basel). 2020 May 25;9(2):18. doi: 10.3390/antib9020018.
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ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives.抗中性粒细胞胞浆抗体相关性血管炎与血液系统恶性肿瘤:从过去到未来的经验教训。
J Immunol Res. 2019 May 6;2019:1732175. doi: 10.1155/2019/1732175. eCollection 2019.
3
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