Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Department of Medical Biology, University of Melbourne, Parkville, Australia.
Oncoimmunology. 2021 Mar 29;10(1):1900508. doi: 10.1080/2162402X.2021.1900508.
Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary lymphoid organs in their composition and structural organization. In contrast to secondary lymphoid organs, TLS are not imprinted during embryogenesis but are formed in non-lymphoid tissues in response to local inflammation. TLS structures exhibiting a variable degree of maturation are found in solid tumors. They are composed of various immune cell types including dendritic cells and antigen-specific B and T lymphocytes, that together, actively drive the immune response against tumor development and progression. This review highlights the successive steps leading to tumor TLS formation and its association with clinical outcomes. We discuss the role played by tumor-infiltrating B lymphocytes and plasma cells, their prognostic value in solid tumors and immunotherapeutic responses and their potential for future targeting.
三级淋巴结构（TLS）是细胞的异位聚集，其组成和结构组织类似于次级淋巴器官。与次级淋巴器官不同，TLS 不是在胚胎发生过程中形成的，而是在非淋巴组织中响应局部炎症而形成的。在实体瘤中可以发现具有不同成熟程度的 TLS 结构。它们由各种免疫细胞类型组成，包括树突状细胞和抗原特异性 B 和 T 淋巴细胞，这些细胞共同积极地驱动针对肿瘤发生和进展的免疫反应。这篇综述强调了导致肿瘤 TLS 形成的连续步骤及其与临床结果的关联。我们讨论了肿瘤浸润 B 淋巴细胞和浆细胞所起的作用，它们在实体瘤中的预后价值以及免疫治疗反应，以及它们在未来靶向治疗中的潜力。
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