Munoz-Erazo Luis, Rhodes Janet L, Marion Valentine C, Kemp Roslyn A
Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Ecole Normale Superieure de Lyon, Lyon, France and Universite Claude Bernard Lyon 1, Lyon, France.
Cell Mol Immunol. 2020 Jun;17(6):570-575. doi: 10.1038/s41423-020-0457-0. Epub 2020 May 15.
Tertiary lymphoid structures (TLS) are ectopic lymphoid formations that form within nonlymphoid tissue. They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region. TLS have been described in several types of cancers and are usually associated with positive patient outcomes. However, TLS differ vastly in cellular composition and location within tissue types. In this review, we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use.
三级淋巴结构（TLS）是在非淋巴组织内形成的异位淋巴组织。它们与二级淋巴结构（如淋巴结）具有结构和功能特征，可包含B细胞滤泡和被T细胞区域包围的生发中心。TLS已在多种癌症类型中被描述，通常与患者的良好预后相关。然而，TLS在细胞组成和组织类型中的位置差异很大。在本综述中，我们讨论了影响对TLS在癌症中预后作用证据解读的因素，并在转化为常规临床应用的背景下阐述了这些因素。
