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一名患有古德综合征患者的木糖氧化无色杆菌/反硝化无色杆菌菌血症

Achromobacter xylosoxidans/denitrificans Bacteremia in a Patient With Good's Syndrome.

作者信息

Choudhury Saiara, Papineni Sudhakar, Ramachandruni Srikanth, Molina Jurairat, Surani Salim

机构信息

Internal Medicine, Corpus Christi Medical Center, Corpus Christi, USA.

Internal Medicine, University of North Texas, Dallas, USA.

出版信息

Cureus. 2021 Mar 11;13(3):e13827. doi: 10.7759/cureus.13827.

DOI:10.7759/cureus.13827
PMID:33854849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8035986/
Abstract

Good's syndrome is a rare, adult-onset immunodeficiency syndrome associated with thymomas. Here, we present a 71-year-old, previously healthy male with a history of opportunistic infections status post-thymectomy, who presented with a septic knee complicated with bacteremia without any inciting factor. Therefore, a diagnosis of Good syndrome was made. While this is a rare disease, clinicians should have a high suspicion in patients with a history of thymoma. Early diagnosis and treatment can reduce opportunistic infections and improve morbidity and mortality.

摘要

古德综合征是一种与胸腺瘤相关的罕见的成人发病免疫缺陷综合征。在此,我们报告一名71岁、既往健康的男性,有胸腺切除术后机会性感染病史,因无任何诱发因素出现膝关节脓毒症并发菌血症。因此,诊断为古德综合征。虽然这是一种罕见疾病,但临床医生对有胸腺瘤病史的患者应高度怀疑。早期诊断和治疗可减少机会性感染,改善发病率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0a/8035986/3e04d76b9b4b/cureus-0013-00000013827-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0a/8035986/a43db57950cf/cureus-0013-00000013827-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0a/8035986/3e04d76b9b4b/cureus-0013-00000013827-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0a/8035986/a43db57950cf/cureus-0013-00000013827-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0a/8035986/3e04d76b9b4b/cureus-0013-00000013827-i02.jpg

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本文引用的文献

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Immunodeficiency and thymoma in Good syndrome: Two sides of the same coin.Good 综合征伴免疫缺陷和胸腺瘤:同一问题的两个方面。
Immunol Lett. 2021 Mar;231:11-17. doi: 10.1016/j.imlet.2020.12.010. Epub 2021 Jan 5.
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Delayed Diagnosis of Good Syndrome.古德综合征的延迟诊断
J Allergy Clin Immunol Pract. 2020 Apr;8(4):1396-1397. doi: 10.1016/j.jaip.2019.11.019. Epub 2019 Dec 12.
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A case of Good's syndrome complicated by erythema multiforme.1例伴有多形红斑的古德综合征。
BMJ Case Rep. 2019 Aug 20;12(8):e229999. doi: 10.1136/bcr-2019-229999.
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Adverse Reactions to Intravenous Immunoglobulins - Our Experience.静脉注射免疫球蛋白的不良反应——我们的经验
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Herpes vegetans accompanied by Good's syndrome.伴有古德综合征的增殖性疱疹。
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Bacteremia in an Immunocompromised Patient.免疫功能低下患者的菌血症
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Septic shock due to Pasteurella multocida bacteremia: a case report.多杀巴斯德菌血症所致脓毒性休克:一例报告
J Med Case Rep. 2015 Jul 11;9:159. doi: 10.1186/s13256-015-0643-3.
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Good syndrome: an adult-onset immunodeficiency remarkable for its high incidence of invasive infections and autoimmune complications.Good 综合征:一种成人发病的免疫缺陷病,其特点是侵袭性感染和自身免疫并发症的发病率高。
Clin Infect Dis. 2015 Jul 15;61(2):e13-9. doi: 10.1093/cid/civ269. Epub 2015 Mar 31.
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Thymoma and autoimmunity.胸腺瘤与自身免疫。
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