Ramezani Mazaher, Siami Shadi, Rezaei Mansour, Khazaei Sedigheh, Sadeghi Masoud
Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Biomedicine (Taipei). 2020 Mar 28;10(1):21-27. doi: 10.37796/2211-8039.1001. eCollection 2020.
Primary brain tumors (PBTs) include any tumor in the brain whose prognosis is weak because of their histological characteristics.
Herein, this study aimed to assess the HER2 tumor marker frequency in PBTs.
This study was done on the samples of primary brain tumor diagnosis from 2008 to 2015.
Out of 107 patients of brain tumor that had a mean age of 40.4 years (61.7% men), the most common location of the tumor was in the supratentorial region (63.85% cases). The prevalence of high-grade astrocytoma (HGA) and low-grade astrocytoma (LGA) at diagnosis was 43.9% and 37.4%, respectively. With regard to HER2 score, HER2-positive (scores 2 & 3) was in 42.1% of patients. On the other hand, HER2-negative (-) was in 57.9%, 2 in 33.6%, and 3 in 8.4% of patients. The patients of LGA had significantly younger ages, lower HER2 positivity, and lower HER2 percent compared with the HGA patients.
The type of brain tumors can impact on HER2 expression that high HER2 expression in HGA may be helpful for therapeutic aims. Further studies are required to support these results with a higher volume of patients in the world.
原发性脑肿瘤（PBTs）包括脑内任何因其组织学特征而预后较差的肿瘤。
本研究旨在评估原发性脑肿瘤中HER2肿瘤标志物的频率。
本研究对2008年至2015年原发性脑肿瘤诊断样本进行。
107例脑肿瘤患者平均年龄40.4岁（男性占61.7%），肿瘤最常见部位是幕上区域（63.85%的病例）。诊断时高级别星形细胞瘤（HGA）和低级别星形细胞瘤（LGA）的患病率分别为43.9%和37.4%。关于HER2评分，HER2阳性（评分2和3）的患者占42.1%。另一方面，HER2阴性（-）的患者占57.9%，评分2的患者占33.6%，评分3的患者占8.4%。与HGA患者相比，LGA患者年龄明显更小，HER2阳性率更低，HER2百分比更低。
脑肿瘤类型可影响HER2表达，HGA中高HER2表达可能有助于治疗目的。需要进一步研究以纳入更多患者来支持这些结果。
