Chang Kuang-Hsi, Teng Chieh-Lin Jerry, Hsu Yi-Chao, Tsai Stella Chin-Shaw, Lin Han-Jie, Hsieh Tsai-Ling, Muo Chih-Hsin, Hsu Chung Y, Chou Ruey-Hwang
Department of Medical Research, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan.
Center for General Education, China Medical University, Taichung 404, Taiwan.
Toxics. 2022 Apr 2;10(4):176. doi: 10.3390/toxics10040176.
Air pollutants as risk factors for benign brain tumor (BBT) remain unclear. Therefore, we conducted a nationwide retrospective cohort study by integrating the patients' clinical data and daily air quality data to assess the environmental risk factors of BBT in Taiwan.Daily air quality data were categorized into quartiles (Q1 to Q4). The adjusted hazard ratio (aHR) was evaluated by comparing the BBT incidence rate of the subjects in Q2-Q4 with that of the subjects in Q1 (the lowest concentration of air pollutants). A total of 161,213 subjects were enrolled in the study. Among the air pollutants tested, the aHR of BBT was significantly higher in the subjects who were exposed to the highest level (Q4) of CO (aHR 1.37, 95% CI 1.08-1.74), NO (aHR 1.40, 95% CI 1.09-1.78), and PM (aHR 1.30, 95% CI 1.02-1.65) than that in the subjects who were exposed to the lowest level (Q1). No significant risk association of BBT with SO and PM exposure was observed. The results revealed that long-term exposure to air pollutants, particularly CO, NO, and PM, is associated with the risk of BBT.
空气污染物作为良性脑肿瘤（BBT）的风险因素仍不明确。因此，我们通过整合患者的临床数据和每日空气质量数据进行了一项全国性的回顾性队列研究，以评估台湾地区BBT的环境风险因素。每日空气质量数据被分为四分位数（Q1至Q4）。通过比较Q2-Q4组受试者与Q1组（空气污染物浓度最低）受试者的BBT发病率来评估调整后的风险比（aHR）。共有161,213名受试者参与了这项研究。在所测试的空气污染物中，暴露于最高水平（Q4）的一氧化碳（aHR 1.37，95%置信区间1.08-1.74）、一氧化氮（aHR 1.40，95%置信区间1.09-1.78）和颗粒物（aHR 1.30，95%置信区间1.02-1.65）的受试者患BBT的aHR显著高于暴露于最低水平（Q1）的受试者。未观察到BBT与二氧化硫和颗粒物暴露之间存在显著的风险关联。结果表明，长期暴露于空气污染物，尤其是一氧化碳、一氧化氮和颗粒物，与BBT风险相关。
