Lai Shih-Wei, Lin Cheng-Li, Liao Kuan-Fu
College of Medicine, China Medical University, Taichung, Taiwan.
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Biomedicine (Taipei). 2020 Mar 28;10(1):40-44. doi: 10.37796/2211-8039.1004. eCollection 2020.
BACKGROUND/OBJECTIVE: No published population-based study investigates the association between hyperuricemia and undiagnosed adult leukemia in Taiwan. The aim of the study was to investigate whether hyperuricemia might be an early manifestation of undiagnosed adult leukemia in Taiwan.
A population-based cohort study was conducted to analyze the database of the Taiwan National Health Insurance Program. There were 47708 subjects aged 20 to 84 years with newly diagnosed hyperuricemia as the hyperuricemia group from 2000 to 2013, and 190832 randomly selected subjects without hyperuricemia as the non-hyperuricemia group. The hyperuricemia group and the non-hyperuricemia group were followed for one year to estimate the incidence of new diagnosis of leukemia.
The overall incidence of leukemia was 1.32-fold higher in the hyperuricemia group than the non-hyperuricemia group (0.74 versus 0.55 per 10000 person-months, 95% confidence interval 1.28-1.37). The incidence rate ratio of leukemia was statistically higher in the first 3 months of hyperuricemia diagnosis (incidence rate ratio 4.05).
Adults with hyperuricemia have a higher incidence of being diagnosed with leukemia than those without hyperuricemia. Hyperuricemia might be an early manifestation of undiagnosed adult leukemia. Clinicians should check the complete blood count with differential to detect the possibility of leukemia when adults present with hyperuricemia.
背景/目的：台湾尚无已发表的基于人群的研究调查高尿酸血症与未确诊的成人白血病之间的关联。本研究的目的是调查高尿酸血症是否可能是台湾未确诊成人白血病的早期表现。
进行了一项基于人群的队列研究，以分析台湾国民健康保险计划的数据库。2000年至2013年，有47708名20至84岁新诊断为高尿酸血症的受试者作为高尿酸血症组，随机选择190832名无高尿酸血症的受试者作为非高尿酸血症组。对高尿酸血症组和非高尿酸血症组进行一年随访，以估计白血病新诊断的发生率。
高尿酸血症组白血病的总体发生率比非高尿酸血症组高1.32倍（每10000人月分别为0.74和0.55，95%置信区间1.28 - 1.37）。在高尿酸血症诊断后的前三个月内，白血病的发病率比值在统计学上更高（发病率比值4.05）。
高尿酸血症的成年人被诊断为白血病的发生率高于无高尿酸血症的成年人。高尿酸血症可能是未确诊成人白血病的早期表现。当成年人出现高尿酸血症时，临床医生应检查全血细胞计数及分类以检测白血病的可能性。
