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抗精神病药物和体位性低血压对精神分裂症患者跌倒风险的影响。

Effect of antipsychotic drugs and orthostatic hypotension on the risk of falling in schizophrenic patients.

作者信息

Ferinauli Ferinauli, Narulita Sari, Hijriyati Yoanita

机构信息

Mental Health Nursing Department, Binawan University, Jakarta.

Basic Nursing Department, Binawan University, Jakarta.

出版信息

J Public Health Res. 2021 Apr 14;10(2):2184. doi: 10.4081/jphr.2021.2184.

DOI:10.4081/jphr.2021.2184
PMID:33855401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8129748/
Abstract

BACKGROUND

Management of schizophrenia using psychopharmaceuticals requires a long-term treatment. The use of antipsychotic drugs can cause the occurrence of orthostatic hypotension, which leads to the risk of falling in patients. The aim of this study is to determine the effect of the use of antipsychotic drugs and orthostatic hypotension on the risk of falling in schizophrenic patients.

DESIGN AND METHODS

This study used a descriptive design with 53 respondents. Data were analyzed using the contingency coefficient correlation and Spearman Rank test methods.

RESULTS

The results of the first study showed no positive effect between the use of antipsychotics on orthostatic hypotension in schizophrenic patients. In addition, a contingency coefficient correlation (C) of 0.199 and p-value of 0.335 (p>0.05) was obtained. The results of the second study showed that there was a significant positive effect between orthostatic hypotension on the risk of falling in schizophrenic patients with a value of r = 0.483 and a p-value of 0.000 (p<0.001).

CONCLUSION

It was suggested that the development of this study's result is needed for further research in dealing with the incidence of orthostatic hypotension in order to prevent or reduce the risk of falling in schizophrenic patients.

摘要

背景

使用精神药物治疗精神分裂症需要长期治疗。抗精神病药物的使用会导致体位性低血压的发生,从而使患者面临跌倒风险。本研究的目的是确定抗精神病药物的使用和体位性低血压对精神分裂症患者跌倒风险的影响。

设计与方法

本研究采用描述性设计,有53名受访者。数据采用列联系数相关性和Spearman秩检验方法进行分析。

结果

第一项研究的结果表明,抗精神病药物的使用与精神分裂症患者的体位性低血压之间没有积极影响。此外,获得的列联系数相关性(C)为0.199,p值为0.335(p>0.05)。第二项研究的结果表明,体位性低血压与精神分裂症患者的跌倒风险之间存在显著的正相关,r值为0.483,p值为0.000(p<0.001)。

结论

建议进一步研究本研究结果的发展,以应对体位性低血压的发生率,从而预防或降低精神分裂症患者的跌倒风险。

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Effect of antipsychotic drugs and orthostatic hypotension on the risk of falling in schizophrenic patients.抗精神病药物和体位性低血压对精神分裂症患者跌倒风险的影响。
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本文引用的文献

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Orthostatic hypotension: From pathophysiology to clinical applications and therapeutic considerations.直立性低血压:从病理生理学到临床应用和治疗考虑。
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Management of common adverse effects of antipsychotic medications.抗精神病药物常见不良反应的管理。
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Orthostatic Hypotension in Middle-Age and Risk of Falls.中年人的直立性低血压与跌倒风险
Am J Hypertens. 2017 Feb;30(2):188-195. doi: 10.1093/ajh/hpw108. Epub 2016 Sep 16.
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The chasm of care: Where does the mental health nursing responsibility lie for the physical health care of people with severe mental illness?照护鸿沟:严重精神障碍患者的躯体健康照护责任应由精神科护理人员承担吗?
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