Departamento de Hematología, Catedra CONACYT, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Domínguez Sección XVI, Delegación Tlalpan C.P, 14080, Mexico City, Mexico.
Departamento de Hematología, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Domínguez Sección XVI, Delegación Tlalpan C.P, 14080, Mexico City, Mexico.
Curr Oncol Rep. 2021 Apr 14;23(6):66. doi: 10.1007/s11912-021-01058-2.
Many prognostic and predictive biomarkers have been proposed for chronic lymphocytic leukaemia (CLL). Here, we aim to discuss the evidence showing a prognostic potential for extracellular vesicles (EV) and their associated microRNAs (miRNAs).
EV are produced by several cells in the body as a physiological event; however, there is evidence suggesting that an elevated EV concentration is present in the circulation of CLL patients. Moreover, some studies have associated EV concentration with advanced Rai stage and unmutated CLL while others have demonstrated its potential as an independent prognostic factor for TTFT and OS. Finally, some studies have shown that CLL EV shared some dysregulated microRNAs with CLL cells and plasma. On the other hand, it was found that CLL EV has a distinctive microRNA expression profile. Until now, EV-associated miR-155 is the most studied miRNA. Despite methodological diversity and limitations in study design, unanimity in CLL EV concentration behaviour and miRNA content has been found.
许多预后和预测生物标志物已被提出用于慢性淋巴细胞白血病（CLL）。在这里，我们旨在讨论证明细胞外囊泡（EV）及其相关 microRNAs（miRNAs）具有预后潜力的证据。
EV 是身体内的几种细胞作为生理事件产生的；然而，有证据表明，CLL 患者的循环中存在升高的 EV 浓度。此外，一些研究将 EV 浓度与晚期 Rai 分期和未突变的 CLL 相关联，而其他研究则证明其作为 TTFT 和 OS 的独立预后因素的潜力。最后，一些研究表明，CLL EV 与 CLL 细胞和血浆中的一些失调 microRNAs 共享。另一方面，发现 CLL EV 具有独特的 microRNA 表达谱。到目前为止，与 EV 相关的 miR-155 是研究最多的 microRNA。尽管在研究设计方面存在方法学多样性和局限性，但在 CLL EV 浓度行为和 miRNA 含量方面已经发现了一致性。
