间充质干细胞治疗慢性伤口的临床研究进展
[Clinical research progress of mesenchymal stem cells in treatment of chronic wounds].
作者信息
Cao Yingxuan, Yan Jianxin, Liu Hongwei
机构信息
Department of Plastic Surgery, the First Affiliated Hospital of Jinan University, Innovative Technology Research Institute of Tissue Repair and Regeneration, Key Laboratory of Regenerative Medicine, Ministry of Education, Guangzhou Guangdong, 510630, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Apr 15;35(4):496-501. doi: 10.7507/1002-1892.202011009.
OBJECTIVE
To review the clinical research progress of mesenchymal stem cells (MSCs) in the treatment of chronic wounds.
METHODS
The literature related to the chronic wound repair with MSCs at home and abroad in recent years was extensively reviewed, and the possible mechanism of MSCs in the treatment of chronic wounds, as well as its application and existing problems were summarized.
RESULTS
MSCs can participate in all aspects of chronic wound healing to promote wound healing, and has shown broad application prospects in clinical trials. MSCs commonly used in clinical research include bone marrow-derived MSCs, adipose-derived tissue MSCs, and umbilical cord-derived MSCs.
CONCLUSION
MSCs treatment is a promising strategy for the chronic wounds, but there are still many problems in its widespread clinical application that require further research.
目的
综述间充质干细胞（MSCs）治疗慢性伤口的临床研究进展。
方法
广泛查阅近年来国内外有关MSCs修复慢性伤口的文献，总结MSCs治疗慢性伤口的可能机制及其应用情况与存在的问题。
结果
MSCs可参与慢性伤口愈合的各个环节以促进伤口愈合，在临床试验中已显示出广阔的应用前景。临床研究中常用的MSCs包括骨髓来源的MSCs、脂肪来源的组织MSCs和脐带来源的MSCs。
结论
MSCs治疗是慢性伤口颇具前景的策略，但在其广泛临床应用中仍存在诸多问题，需要进一步研究。
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