脐带间充质干细胞通过自噬清除糖尿病伤口晚期糖基化终产物的临床应用前景
Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound.
作者信息
Han Yanfu, Sun Tianjun, Tao Ran, Han Yanqing, Liu Jing
机构信息
Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyilu, Yangfangdian, Haidian District, Beijing, 100038, People's Republic of China.
Department of Burn and Plastic Surgery, Hainan Branch of People's Liberation Army General Hospital, Haitangwan, Sanya, People's Republic of China.
出版信息
Eur J Med Res. 2017 Mar 24;22(1):11. doi: 10.1186/s40001-017-0253-1.
Abstract
Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.
摘要
如今，糖尿病导致的伤口愈合延迟被认为与晚期糖基化终末产物（AGEs）的积累密切相关。尽管间充质干细胞（MSCs）对糖尿病伤口愈合具有积极作用，但其相关机制仍未完全阐明。据报道，MSCs可提高受损组织中的自噬活性，从而在伤口愈合中发挥重要作用。MSCs诱导的自噬可能通过清除AGEs对糖尿病伤口愈合有益，这为糖尿病伤口的临床治疗提供了新思路，具有广阔的应用前景。在本研究中，综述了脐带源MSCs在糖尿病伤口AGEs清除方面的研究现状及应用前景。
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Cell Physiol Biochem. 2016;38(1):258-66. doi: 10.1159/000438627. Epub 2016 Jan 20.
2
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3
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