VEGF-B 和 FLT-1 的共表达与胃癌的恶性程度和预后相关。

Co-expression of VEGF-B and FLT-1 correlates with malignancy and prognosis of gastric cancer.

机构信息

Department of General Surgery of East District, Second Hospital of Hebei Medical University, no. 215 Heping East Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.

Department of Vascular Surgery, Second Hospital of Hebei Medical University, no. 215 Heping East Road, Xinhua District, Shijiazhuang, 050000, Hebei, China.

出版信息

Biomark Med. 2021 May;15(7):481-488. doi: 10.2217/bmm-2020-0608. Epub 2021 Apr 15.

DOI:10.2217/bmm-2020-0608

PMID:33856262

Abstract

This study aims to investigate the correlation of VEGF-B and FLT-1 co-expression with the prognosis of gastric cancer (GC). Primary GC samples and adjacent tissues were obtained from 96 patients. Both VEGF-B and FLT-1 were testified to be upregulated in the human GC compared with adjacent tissues. Spearman's rank correlation analysis indicated that VEGF-B and FLT-1 expression were correlated (r = 0.321, p = 0.0015). High VEGF-B and FLT-1 co-expression patients showed poor prognosis when compared with low VEGF-B and FLT-1 co-expression patients (p = 0.0169). The high co-expression of VEGF-B and FLT-1 in GC shows a poor prognosis of overall survival, and targeted therapy against the interaction between VEGF-B and FLT-1 is worth further detailed analysis.

摘要

本研究旨在探讨 VEGF-B 和 FLT-1 共表达与胃癌（GC）预后的相关性。收集 96 例原发性 GC 样本及其相邻组织。与相邻组织相比，人 GC 中 VEGF-B 和 FLT-1 的表达均上调。Spearman 秩相关分析表明，VEGF-B 和 FLT-1 的表达呈正相关（r=0.321，p=0.0015）。与 VEGF-B 和 FLT-1 低共表达患者相比，VEGF-B 和 FLT-1 高共表达患者预后较差（p=0.0169）。GC 中 VEGF-B 和 FLT-1 的高共表达提示总生存期预后不良，针对 VEGF-B 和 FLT-1 相互作用的靶向治疗值得进一步详细分析。