AIE Institute, Center for Aggregation-Induced Emission, State Key Laboratory of Luminescent Materials and Devices, Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province, South China University of Technology, Guangzhou 510640, China.
Shenzhen Institute of Aggregate Science and Technology, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China.
ACS Nano. 2021 Apr 27;15(4):7735-7743. doi: 10.1021/acsnano.1c01577. Epub 2021 Apr 15.
The utilization of photochemical reaction channel based on radical process is rarely reported, which might be a very efficient and feasible strategy for improving generation of Type I reactive oxygen species (ROS). In this work, a double ionic-type aggregation-induced emission luminogen (AIEgen) of TIdBO was developed as a photosensitizer, of which the potential photocyclization characteristic involving an electron-transfer process had a positive effect on Type I ROS generation in aggregates under continuous light irradiation. Its noticeable photodynamic therapy (PDT) performance and self-monitoring of PDT process by the relationship between cellular morphology change and fluorescence intensity enhancement were achieved. In addition, it showed a good killing ability to microbes and specific interactions with microbes but not cells by regulating the incubation time. These intriguing results reveal a feasible design principle for the implementation of efficient PS preparation in clinical treatment under hypoxic conditions.
基于自由基过程的光化学反应通道的利用很少有报道，这可能是提高 I 型活性氧（ROS）生成的非常有效和可行的策略。在这项工作中，开发了一种双离子型聚集诱导发射发光剂（AIEgen）TIdBO 作为光敏剂，其涉及电子转移过程的潜在光环化特性对连续光照下聚集物中 I 型 ROS 的生成有积极影响。通过细胞形态变化与荧光强度增强之间的关系，实现了其显著的光动力治疗（PDT）性能和 PDT 过程的自我监测。此外，通过调节孵育时间，它对微生物具有良好的杀伤能力，并与微生物具有特异性相互作用，而与细胞没有相互作用。这些有趣的结果为在缺氧条件下实现临床治疗中高效 PS 制剂的设计提供了可行的设计原则。
