Li Jianqing, Zhuang Zeyan, Lou Xiaoding, Zhao Zujin, Tang Ben Zhong
State Key Laboratory of Luminescent Materials and Devices, Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province, South China University of Technology, Guangzhou 510640, China.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Chem Biomed Imaging. 2023 May 19;1(9):785-795. doi: 10.1021/cbmi.3c00038. eCollection 2023 Dec 25.
Photochemical reaction is expected to become a promising type of green chemistry with merits of operational flexibility, excellent regioselectivity, high yield, and mild reaction condition. Recently, aggregation-induced emission (AIE)-based fluorescent molecules with photoresponsivity have been quickly developed and employed in the biomedical field. In this Review, photoresponsive AIE materials based on the inherent photochemical reactions are highlighted according to the photochemical pathways: photoisomerization, photocyclization, photodimerization, and multiple photoreactions. Following this, their biomedical applications are summarized and discussed, including photoactivatable bioimaging, diagnosis, and therapy. Finally, the challenges and future perspectives are presented.
光化学反应有望成为一种具有前景的绿色化学类型，具有操作灵活性、出色的区域选择性、高收率和温和反应条件等优点。近年来，具有光响应性的基于聚集诱导发光（AIE）的荧光分子得到了迅速发展，并应用于生物医学领域。在本综述中，基于固有光化学反应的光响应性AIE材料根据光化学途径进行了重点介绍：光异构化、光环化、光二聚化和多重光反应。在此之后，总结并讨论了它们的生物医学应用，包括光激活生物成像、诊断和治疗。最后，提出了挑战和未来展望。
