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发展中国家前列腺癌筛查、诊断和分期工具的共识:来自第一届发展中国家前列腺癌共识会议(PCCCDC)的报告。

Consensus on Screening, Diagnosis, and Staging Tools for Prostate Cancer in Developing Countries: A Report From the First Prostate Cancer Consensus Conference for Developing Countries (PCCCDC).

机构信息

Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

Hospital Beneficiencia Portuguesa de São Paulo, São Paulo, Brazil.

出版信息

JCO Glob Oncol. 2021 Apr;7:516-522. doi: 10.1200/GO.20.00527.

Abstract

PURPOSE

To generate and present the survey results on critical issues relevant to screening, diagnosis, and staging tools for prostate cancer (PCa) focused on developing countries.

METHODS

A total of 36 of 300 questions concern the main areas of interest of this paper: (1) screening, (2) diagnosis, and (3) staging for various risk levels of PCa in developing countries. A panel of 99 international multidisciplinary cancer experts voted on these questions to create recommendations for screening, diagnosing, and staging tools for PCa in areas of limited resources discussed in this manuscript.

RESULTS

The panel voted publicly but anonymously on the predefined questions. Each question was deemed consensus if 75% or more of the full panel had selected a particular answer. These answers are based on panelist opinion not a literature review or meta-analysis. For questions that refer to an area of limited resources, the recommendations consider cost-effectiveness and the possible therapies with easier and greater access. Each question had five to seven relevant answers including two nonanswers. The results were tabulated in real time.

CONCLUSION

The voting results and recommendations presented in this document can be used by physicians to support the screening, diagnosis, and staging of PCa in areas of limited resources. Individual clinical decision making should be supported by available data; however, as guidelines for screening, diagnosis, and staging of PCa in developing countries have not been developed, this document will serve as a point of reference when confronted with this disease.

摘要

目的

生成并呈现与发展中国家前列腺癌(PCa)的筛查、诊断和分期工具相关的关键问题的调查结果。

方法

在 300 个问题中,共有 36 个问题集中在本文的主要关注领域:(1)发展中国家不同 PCa 风险水平的筛查,(2)诊断,和(3)分期。一个由 99 名国际多学科癌症专家组成的小组对这些问题进行了投票,为本文讨论的资源有限地区的 PCa 筛查、诊断和分期工具制定了建议。

结果

小组成员公开但匿名对预先定义的问题进行了投票。如果超过 75%的全体小组成员选择了特定的答案,则认为该问题达成共识。这些答案基于小组成员的意见,而不是文献综述或荟萃分析。对于涉及资源有限领域的问题,建议考虑成本效益以及具有更简单和更大可及性的可能疗法。每个问题都有五个到七个相关答案,包括两个非答案。结果实时进行了制表。

结论

本文呈现的投票结果和建议可被医生用于支持资源有限地区的 PCa 的筛查、诊断和分期。个体临床决策应得到现有数据的支持;然而,由于尚未制定发展中国家 PCa 的筛查、诊断和分期指南,因此当遇到这种疾病时,本文将作为参考点。

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