新型冠状病毒肺炎与心血管疾病：从基础到临床。
COVID-19 and Cardiovascular Disease: From Bench to Bedside.
机构信息
Cleveland Clinic (M.K.C., S.J.C., T.C., D.H.K., T.S., J.B.), OH.
Cleveland Clinic Lerner College of Medicine (M.K.C., S.J.C., T.C., D.H.K., T.S., J.B.), OH.
出版信息
Circ Res. 2021 Apr 16;128(8):1214-1236. doi: 10.1161/CIRCRESAHA.121.317997. Epub 2021 Apr 15.
Abstract
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
摘要
一场具有历史影响的大流行，即 2019 年冠状病毒病（COVID-19），可能对全球范围内感染后幸存的数百万人的心血管健康产生潜在影响。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是 COVID-19 的病原体，可通过血管紧张素转换酶 2（ACE2，病毒刺突蛋白的宿主细胞受体）感染心脏、血管组织和循环细胞。急性心脏损伤是 COVID-19 的一种常见肺外表现，并有潜在的慢性后果。本更新提供了对心血管受累的临床表现、潜在直接影响心血管系统的 SARS-CoV-2 和间接免疫反应机制以及对急性 COVID-19 感染后患者管理的影响的综述。
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