Evans M I, Koppich F C, Nemitz B, Quigg M H, Zador I E
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, MI 48201.
J Reprod Med. 1988 May;33(5):450-2.
At centers where chorionic villus sampling (CVS) programs are operational, first-trimester prenatal diagnosis has been shown to have many advantages, both medical and psychologic. However, most medical centers do not have CVS capability, nor are all patients candidates for CVS. We investigated the feasibility of performing very early genetic amniocentesis (9-13 weeks' gestational age). The results from those amniocenteses were compared to our own CVS data. In experienced hands, (1) CVS can be performed safely at 8-13 weeks, with the most technical ease at 9-11 weeks; (2) CVS or amniocentesis can be performed on many patients at 12-13 weeks or perhaps even earlier, although no accurate loss rates are available yet; (3) when technically feasible, CVS may be advantageous because of the much faster time period for cytogenetic results from direct preparation or short-term culture; and (4) in those patients on whom CVS cannot be performed, early amniocentesis in selected patients may offer the benefits of early diagnosis.
在开展绒毛取样（CVS）项目的医疗中心，早孕期产前诊断已显示出诸多医学和心理方面的优势。然而，大多数医疗中心不具备进行CVS的能力，而且并非所有患者都适合做CVS。我们研究了在孕9至13周进行极早期遗传羊膜腔穿刺术的可行性。将这些羊膜腔穿刺术的结果与我们自己的CVS数据进行了比较。在经验丰富的医生手中，（1）CVS可在孕8至13周安全进行，在孕9至11周技术操作最为简便；（2）CVS或羊膜腔穿刺术可在许多患者孕12至13周甚至更早时进行，尽管目前尚无准确的流产率数据；（3）在技术可行时，CVS可能更具优势，因为直接制片或短期培养获得细胞遗传学结果的时间要快得多；（4）对于那些无法进行CVS的患者，在部分选定患者中进行早期羊膜腔穿刺术可能会带来早期诊断的益处。
