Donnenfeld A E, Librizzi R J, Dunn L K, Craparo F, Godmilow L, Weiner S
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107.
Am J Med Genet. 1993 Feb 1;45(3):361-4. doi: 10.1002/ajmg.1320450316.
In our consecutive series of 2,574 chorionic villus sampling (CVS) patients, 146 women (5.7%) underwent a subsequent amniocentesis in the same pregnancy for the indications of absent or insufficient villi (3.3%), elevated maternal serum alpha-fetoprotein (0.93%), CVS mosaicism (0.89%), culture failure (0.23%), specimen contamination (0.15%), and CVS aneuploidy (0.12%). Patients presenting for a CVS should be informed of the possible need for a subsequent amniocentesis in the same pregnancy. There is a need for individual prenatal diagnosis programs to analyze their own data and provide genetic counseling information which pertains specifically to their institution.
在我们连续纳入的2574例绒毛取样（CVS）患者中，146名女性（5.7%）在同一孕期因绒毛缺乏或不足（3.3%）、孕妇血清甲胎蛋白升高（0.93%）、CVS嵌合体（0.89%）、培养失败（0.23%）、样本污染（0.15%）以及CVS非整倍体（0.12%）等指征而接受了后续羊水穿刺。接受CVS检查的患者应被告知在同一孕期可能需要进行后续羊水穿刺。各产前诊断项目需要分析自身数据，并提供专门适用于其机构的遗传咨询信息。
