University Center for Research and Development, Chandigarh University, Gharuan, Punjab, 140413, India.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, 160 062, Punjab, India.
Eur J Med Chem. 2021 Jul 5;219:113378. doi: 10.1016/j.ejmech.2021.113378. Epub 2021 Mar 24.
Biguanides are compounds in which two guanidine moieties are fused to form a highly conjugated system. Biguanides are highly basic and hence they are available as salts mostly hydrochloride salts, these cationic species have been found to exhibit many therapeutic properties. This review covers the research and development carried out on biguanides and accounts the various therapeutic applications of drugs containing biguanide group-such as antimalarial, antidiabetic, antiviral, anticancer, antibacterial, antifungal, anti-tubercular, antifilarial, anti-HIV, as well as other biological activities. The aim of this review is to compile all the medicinal chemistry applications of this class of compounds so as to pave way for the accelerated efforts in finding the drug action mechanisms associated with this class of compounds. Importance has been given to the organic chemistry of these biguanide derivatives also.
双胍类化合物是由两个胍基部分融合形成的高度共轭体系的化合物。双胍类化合物具有很强的碱性，因此它们主要以盐的形式存在，通常是盐酸盐，这些阳离子物种已被发现具有许多治疗特性。本综述涵盖了对双胍类化合物的研究和开发，并介绍了含有双胍基团的药物的各种治疗应用，如抗疟、抗糖尿病、抗病毒、抗癌、抗菌、抗真菌、抗结核、抗丝虫、抗 HIV 以及其他生物活性。本综述的目的是编译这一类化合物的所有药物化学应用，为加速寻找与这一类化合物相关的药物作用机制铺平道路。本综述还特别强调了这些双胍类衍生物的有机化学。
