• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

二甲双胍治疗 2 型糖尿病和乳酸酸中毒的新视角。

A new perspective on the biguanide, metformin therapy in type 2 diabetes and lactic acidosis.

机构信息

Department of Internal Medicine, Chubu Rosai Hospital, Japan Organization of Occupational Health and Safety, Nagoya, Japan.

出版信息

J Diabetes Investig. 2019 Jul;10(4):906-908. doi: 10.1111/jdi.13090.

DOI:10.1111/jdi.13090
PMID:31152685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6626960/
Abstract

Recent topics about metformin mainly focus on clinical studies, briefly mentioning some new aspects on the mechanisms of metformin action.

摘要

最近关于二甲双胍的研究主要集中在临床研究方面，简要提到了一些关于二甲双胍作用机制的新方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cef/6626960/45fb3b52d071/JDI-10-906-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cef/6626960/45fb3b52d071/JDI-10-906-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cef/6626960/45fb3b52d071/JDI-10-906-g001.jpg

相似文献

1
A new perspective on the biguanide, metformin therapy in type 2 diabetes and lactic acidosis.二甲双胍治疗 2 型糖尿病和乳酸酸中毒的新视角。
J Diabetes Investig. 2019 Jul;10(4):906-908. doi: 10.1111/jdi.13090.
2
Biguanide-associated lactic acidosis. Case report and review of the literature.双胍类药物相关乳酸酸中毒。病例报告及文献综述。
Arch Intern Med. 1992 Nov;152(11):2333-6. doi: 10.1001/archinte.152.11.2333.
3
The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.补充硫胺素后，一名患有双胍类药物相关严重乳酸酸中毒的患者戏剧性康复。
Intern Med. 2017;56(4):455-459. doi: 10.2169/internalmedicine.56.7754. Epub 2017 Feb 15.
4
[Value of biguanide in therapy of diabetes mellitus].[双胍类药物在糖尿病治疗中的价值]
Med Klin (Munich). 1997 Aug 15;92(8):472-9, 505. doi: 10.1007/BF03044916.
5
[Therapeutic utility of biguanides in the treatment of NIDDM].双胍类药物在非胰岛素依赖型糖尿病治疗中的治疗效用
Nihon Rinsho. 1999 Mar;57(3):657-62.
6
Metformin and lactic acidosis during shock: just the tip of the iceberg?休克期间的二甲双胍与乳酸性酸中毒：只是冰山一角？
Crit Care. 2016 Jun 1;20(1):158. doi: 10.1186/s13054-016-1333-2.
7
Metformin: prevention of lactic acidosis.二甲双胍：预防乳酸性酸中毒。
Urol Nurs. 1996 Jun;16(2):71-2.
8
Metformin: When Should We Fear Lactic Acidosis?二甲双胍：我们何时应担心乳酸酸中毒？
Int J Mol Sci. 2022 Jul 28;23(15):8320. doi: 10.3390/ijms23158320.
9
Clinical pharmacology physiology conference: metformin and lactic acidosis (LA).临床药理生理学会议：二甲双胍与乳酸性酸中毒（LA）
Int Urol Nephrol. 2002;34(3):419-23. doi: 10.1023/a:1024456402584.
10
Lactic acidosis. Lactic acidosis associated with metformin use in treatment of type 2 diabetes mellitus.乳酸性酸中毒。与二甲双胍用于治疗2型糖尿病相关的乳酸性酸中毒。
Geriatrics. 2005 Nov;60(11):36, 39-41.

引用本文的文献

1
Potential Mechanisms of the Improvement of Glucose Homeostasis in Type 2 Diabetes by Pomegranate Juice.石榴汁改善2型糖尿病患者血糖稳态的潜在机制
Antioxidants (Basel). 2022 Mar 15;11(3):553. doi: 10.3390/antiox11030553.
2
In Silico Approaches to Identify Polyphenol Compounds as α-Glucosidase and α-Amylase Inhibitors against Type-II Diabetes.计算机辅助方法鉴定多酚类化合物作为 II 型糖尿病的α-葡萄糖苷酶和α-淀粉酶抑制剂
Biomolecules. 2021 Dec 14;11(12):1877. doi: 10.3390/biom11121877.
3
Adverse Effects of Metformin From Diabetes to COVID-19, Cancer, Neurodegenerative Diseases, and Aging: Is VDAC1 a Common Target?

本文引用的文献

1
Efficacy of metformin on postprandial plasma triglyceride concentration by administration timing in patients with type 2 diabetes mellitus: A randomized cross-over pilot study.二甲双胍给药时机对 2 型糖尿病患者餐后血浆三酰甘油浓度的影响：一项随机交叉先导研究。
J Diabetes Investig. 2019 Sep;10(5):1284-1290. doi: 10.1111/jdi.13016. Epub 2019 Feb 22.
2
3. Prevention or Delay of Type 2 Diabetes: .3. 预防或延缓 2 型糖尿病： 。
Diabetes Care. 2019 Jan;42(Suppl 1):S29-S33. doi: 10.2337/dc19-S003.
3
Which is better, high-dose metformin monotherapy or low-dose metformin/linagliptin combination therapy, in improving glycemic variability in type 2 diabetes patients with insufficient glycemic control despite low-dose metformin monotherapy? A randomized, cross-over, continuous glucose monitoring-based pilot study.
二甲双胍的不良反应：从糖尿病到新冠病毒病、癌症、神经退行性疾病及衰老——电压依赖性阴离子通道1是共同靶点吗？
Front Physiol. 2021 Oct 4;12:730048. doi: 10.3389/fphys.2021.730048. eCollection 2021.
4
Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF-B Signaling Pathway.白果内酯通过调节HMGB1/TLR4/NF-κB信号通路增强AMPK活性，改善链脲佐菌素诱导的未成熟大鼠糖尿病模型中的肝损伤和代谢紊乱。
Biomed Res Int. 2021 Apr 17;2021:8835408. doi: 10.1155/2021/8835408. eCollection 2021.
5
Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects.依格列净与格列美脲在健康男性受试者中的药代动力学/药效学相互作用。
Drug Des Devel Ther. 2020 Nov 24;14:5179-5187. doi: 10.2147/DDDT.S275343. eCollection 2020.
哪种方案更优，即高剂量二甲双胍单药治疗或低剂量二甲双胍/利格列汀联合治疗，能改善经低剂量二甲双胍单药治疗血糖控制仍不佳的 2 型糖尿病患者的血糖变异性？一项基于连续血糖监测的随机、交叉、先导性研究。
J Diabetes Investig. 2019 May;10(3):714-722. doi: 10.1111/jdi.12922. Epub 2018 Oct 9.
4
Effects of metformin and alogliptin on body composition in people with type 2 diabetes.二甲双胍和阿格列汀对 2 型糖尿病患者身体成分的影响。
J Diabetes Investig. 2019 May;10(3):723-730. doi: 10.1111/jdi.12920. Epub 2018 Oct 25.
5
Effects of liraglutide, metformin and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: A randomized trial.利拉鲁肽、二甲双胍和格列齐特对 2 型糖尿病合并非酒精性脂肪肝患者体成分的影响：一项随机试验。
J Diabetes Investig. 2019 Mar;10(2):399-407. doi: 10.1111/jdi.12888. Epub 2018 Aug 16.
6
Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study.二甲双胍使用与肾功能范围内乳酸酸中毒风险的关联：一项基于社区的队列研究。
JAMA Intern Med. 2018 Jul 1;178(7):903-910. doi: 10.1001/jamainternmed.2018.0292.
7
Mechanisms of metformin action: In and out of the gut.二甲双胍作用机制：肠内与肠外。
J Diabetes Investig. 2018 Jul;9(4):701-703. doi: 10.1111/jdi.12864. Epub 2018 Jun 5.
8
Failure of monotherapy in clinical practice in patients with type 2 diabetes: The Korean National Diabetes Program.临床实践中 2 型糖尿病患者单药治疗失败：韩国国家糖尿病计划。
J Diabetes Investig. 2018 Sep;9(5):1144-1152. doi: 10.1111/jdi.12801. Epub 2018 Feb 9.
9
High-volume continuous venovenous hemodiafiltration plus resin hemoperfusion improves severe metformin-associated toxicity.高容量连续性静脉-静脉血液透析滤过联合树脂血液灌流改善严重二甲双胍相关性中毒。
J Diabetes Investig. 2018 Jul;9(4):975-978. doi: 10.1111/jdi.12757. Epub 2017 Dec 6.
10
Effects of dosage and dosing frequency on the efficacy and safety of high-dose metformin in Japanese patients with type 2 diabetes mellitus.剂量和给药频率对日本2型糖尿病患者大剂量二甲双胍疗效及安全性的影响。
J Diabetes Investig. 2017 Sep 30;9(3):587-93. doi: 10.1111/jdi.12755.