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老年人髋部骨折后精神障碍的发病率增加:一项全国性队列研究。

The incidence of mental disorder increases after hip fracture in older people: a nationwide cohort study.

机构信息

School of Medicine, Tzu Chi University, Hualien, Taiwan.

Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 707, ChungYang Rd., Hualien, Taiwan.

出版信息

BMC Geriatr. 2021 Apr 15;21(1):249. doi: 10.1186/s12877-021-02195-w.

Abstract

BACKGROUND

People living with dementia seem to be more likely to experience delirium following hip fracture. The association between mental disorders (MD) and hip fracture remains controversial. We conducted a nationwide study to examine the prevalence of MD in geriatric patients with hip fractures undergoing surgery and conducted a related risk factor analysis.

MATERIAL AND METHODS

This retrospective cohort study used data from Taiwan's National Health Insurance Research Database between 2000 and 2012 and focused on people who were older than 60 years. Patients with hip fracture undergoing surgical intervention and without hip fracture were matched at a ratio of 1:1 for age, sex, comorbidities, and index year. The incidence and hazard ratios of age, sex, and multiple comorbidities related to MD and its subgroups were calculated using Cox proportional hazards regression models.

RESULTS

A total of 1408 patients in the hip fracture group and a total of 1408 patients in the control group (no fracture) were included. The overall incidence of MD for the hip fracture and control groups per 100 person-years were 0.8 and 0.5, respectively. Among MD, the incidences of transient MD, depression, and dementia were significantly higher in the hip fracture group than in the control group.

CONCLUSIONS

The prevalence of newly developed MD, especially transient MD, depression, and dementia, was higher in the geriatric patients with hip fracture undergoing surgery than that in the control group. Prompt and aggressive prevention protocols and persistent follow-up of MD development is highly necessary in this aged society.

摘要

背景

患有痴呆症的人在髋部骨折后似乎更容易出现意识混乱。精神障碍(MD)与髋部骨折之间的关联仍存在争议。我们进行了一项全国性研究,以检查接受手术治疗的老年髋部骨折患者中 MD 的患病率,并进行了相关的危险因素分析。

材料和方法

这项回顾性队列研究使用了台湾国家健康保险研究数据库 2000 年至 2012 年的数据,研究对象为年龄大于 60 岁的人群。接受手术干预的髋部骨折患者和未发生髋部骨折的患者按照年龄、性别、合并症和指数年进行 1:1 匹配。使用 Cox 比例风险回归模型计算与 MD 及其亚组相关的年龄、性别和多种合并症的发生率和危险比。

结果

髋部骨折组共有 1408 例患者,对照组(无骨折)共有 1408 例患者。髋部骨折组和对照组的 MD 总发生率为每 100 人年 0.8 和 0.5。在 MD 中,髋部骨折组的短暂性 MD、抑郁症和痴呆症的发生率明显高于对照组。

结论

在接受手术治疗的老年髋部骨折患者中,新发 MD,特别是短暂性 MD、抑郁症和痴呆症的发生率高于对照组。在这个老龄化社会中,迫切需要制定并积极执行预防方案,并持续关注 MD 的发展情况。

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