Huang Jiaxin, Zhang Han, You Lingtong, Zhang Jinning, Jiang Zhixian
Inpatient Department District N13, Quanzhou First Hospital Affiliated to Fujian Medical University, Chendong Branch of Quanzhou First Hospital, Quanzhou, Fujian, China.
Pediatr Res. 2022 Mar;91(4):839-845. doi: 10.1038/s41390-021-01512-8. Epub 2021 Apr 15.
The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10), a commonly used nutritional supplement, on intracranial aneurysm (IA) initiation and progression in a mouse model, as well as the mechanism.
Hydrogen peroxide (HO) was used to treat mouse-derived vascular smooth muscle cells (VSMCs) to induce oxidative injury, followed by incubation with CoQ10. In the mouse IA model established by elastase injection, CoQ10 was orally administered at 10 mg/kg every other day for 14 days, during which the incidence of IA, rupture rate, symptom-free survival, and systolic blood pressure were recorded.
CoQ10 promoted the expression of nuclear factor erythroid 2-related factor 2 and antioxidant enzymes. In HO-treated VSMCs, reactive oxygen species and cell apoptosis were reduced by CoQ10. In IA mice, CoQ10 treatment decreased the rupture rate of IA, improved the symptom-free survival, and reduced systolic blood pressure. Macrophage infiltration and expression of pro-inflammatory cytokines in the cerebral arteries were mitigated by CoQ10 treatment.
CoQ10 is effective in reducing oxidative stress in VSMCs, thereby attenuating IA formation and rupture in mice. CoQ10 also alleviates inflammation and restores normal phenotypes of VSMCs in the cerebral arteries. Our data suggest that CoQ10 is a potentially effective drug for managing IA.
To investigate the effect of CoQ10, a commonly used nutritional supplement, on IA initiation and progression in a mouse model, as well as the mechanism. CoQ10 promoted the expression of Nrf2 and antioxidant enzymes. In HO-treated VSMCs, ROS and cell apoptosis were reduced by CoQ10. CoQ10 is effective in reducing oxidative stress in VSMCs, thereby attenuating IA formation and rupture in mice.
本研究旨在探讨常用营养补充剂辅酶Q10（CoQ10）对小鼠模型中颅内动脉瘤（IA）起始和进展的影响及其机制。
用过氧化氢（HO）处理小鼠来源的血管平滑肌细胞（VSMC）以诱导氧化损伤，随后用CoQ10孵育。在通过弹性蛋白酶注射建立的小鼠IA模型中，每隔一天口服给予CoQ10，剂量为10mg/kg，持续14天，在此期间记录IA的发生率、破裂率、无症状生存期和收缩压。
CoQ10促进核因子红细胞2相关因子2和抗氧化酶的表达。在HO处理的VSMC中，CoQ10降低了活性氧和细胞凋亡。在IA小鼠中，CoQ10治疗降低了IA的破裂率，改善了无症状生存期，并降低了收缩压。CoQ10治疗减轻了脑动脉中的巨噬细胞浸润和促炎细胞因子的表达。
CoQ10可有效降低VSMC中的氧化应激，从而减轻小鼠IA的形成和破裂。CoQ10还可减轻炎症并恢复脑动脉中VSMC的正常表型。我们的数据表明CoQ10是一种治疗IA的潜在有效药物。
探讨常用营养补充剂CoQ10对小鼠模型中IA起始和进展的影响及其机制。CoQ10促进Nrf2和抗氧化酶的表达。在HO处理的VSMC中，CoQ10降低了活性氧和细胞凋亡。CoQ10可有效降低VSMC中的氧化应激，从而减轻小鼠IA的形成和破裂。
