Zaman Raiyan T, Diagaradjane Parmeswaran, Wang James C, Schwartz Jon, Rajaram Narasimhan, Gill-Sharp Kelly L, Cho Sang H, Rylander Henry Grady, Payne J Donald, Krishnan Sunil, Tunnell James W
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712 USA.
Radiation Oncology, MD Anderson Cancer Center, Houston, TX 77030-4090 USA.
IEEE J Sel Top Quantum Electron. 2007 Nov-Dec;13(6):1715-1720. doi: 10.1109/jstqe.2007.910804.
This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500-800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed studies on tissue phantoms illustrating an accurate measurement of gold-silica nanoshell concentration within 12.6% of the known concentration. studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis.
本研究展示了利用漫射光学光谱（DOS）对活小鼠肿瘤中金纳米壳浓度进行无创测量。我们使用与组织表面接触的光纤探头测量漫射光谱（500 - 800纳米）。我们对组织模型进行了研究，结果表明能准确测量金 - 二氧化硅纳米壳浓度，测量值在已知浓度的12.6%范围内。我们还对小鼠异种移植肿瘤模型进行了研究。在注射前、注射后即刻、注射后1小时和24小时测量DOS光谱，并使用中子活化分析验证纳米壳浓度。
