利用漫射光谱法检测肿瘤中的金纳米壳
Detection of Gold Nanoshells in Tumors Using Diffuse Optical Spectroscopy.
作者信息
Zaman Raiyan T, Diagaradjane Parmeswaran, Wang James C, Schwartz Jon, Rajaram Narasimhan, Gill-Sharp Kelly L, Cho Sang H, Rylander Henry Grady, Payne J Donald, Krishnan Sunil, Tunnell James W
机构信息
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712 USA.
Radiation Oncology, MD Anderson Cancer Center, Houston, TX 77030-4090 USA.
出版信息
IEEE J Sel Top Quantum Electron. 2007 Nov-Dec;13(6):1715-1720. doi: 10.1109/jstqe.2007.910804.
Abstract
This study demonstrates the use of diffuse optical spectroscopy (DOS) for the noninvasive measurement of gold nanoshell concentrations in tumors of live mice. We measured the diffuse optical spectra (500-800 nm) using an optical fiber probe placed in contact with the tissue surface. We performed studies on tissue phantoms illustrating an accurate measurement of gold-silica nanoshell concentration within 12.6% of the known concentration. studies were performed on a mouse xenograft tumor model. DOS spectra were measured at preinjection, immediately postinjection, 1 and 24 h postinjection times, and the nanoshell concentrations were verified using neutron activation analysis.
摘要
本研究展示了利用漫射光学光谱（DOS）对活小鼠肿瘤中金纳米壳浓度进行无创测量。我们使用与组织表面接触的光纤探头测量漫射光谱（500 - 800纳米）。我们对组织模型进行了研究，结果表明能准确测量金 - 二氧化硅纳米壳浓度，测量值在已知浓度的12.6%范围内。我们还对小鼠异种移植肿瘤模型进行了研究。在注射前、注射后即刻、注射后1小时和24小时测量DOS光谱，并使用中子活化分析验证纳米壳浓度。
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