Sun Minghua, Li Hua, Liu Jing, Ning Lirong, Zhao Dongjie, Liu Shiyong
Department of Oncology, Zhongmeng Hospital, Zhalantun, China.
Department of Oncology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Minerva Med. 2021 Jun;112(3):359-364. doi: 10.23736/S0026-4806.20.06444-7. Epub 2020 Mar 12.
To explore the TEM8 expression in patients with lung cancer and its relationship with clinical pathology and prognosis, and to analyze the diagnostic value of TEM8.
A total of 204 patients with lung cancer diagnosed and treated in Zhongmeng Hospital Zhalantun and the First Affiliated Hospital of Jinzhou Medical University from March 2013 to February 2016 were enrolled in the study group, and 203 healthy subjects in the control group. qRT-PCR technique was applied to detect the TEM8 expression. Combined with clinical information, the diagnostic value of TEM8 for lung cancer and the correlation of clinical characteristics of TEM8 were analyzed. The 3-year survival curves of patients with low and high TEM8 expressions were compared.
The expression in the study group was significantly higher than that in the control group (P<0.05). When the cut-off value was 1.125, the sensitivity, specificity and AUC of TEM8 in the diagnosis of lung cancer were 50.00%, 98.00% and 0.726 respectively. The TEM8 expression also differs when in smoking, lymphatic metastasis, TNM stage, differentiation degree and pleural invasion classification (P<0.050). 132 patients were included in the survival group and 72 patients were included in the death group. There was a difference between the two groups in the effect of TEM8 on the prognosis (P<0.001).
TEM8 showed high expression in the study group. TEM8 had good diagnostic efficacy and was expected to be an excellent indicator for early clinical diagnosis and prognosis of lung cancer.
探讨肺癌患者中嗜唾素8（TEM8）的表达情况及其与临床病理和预后的关系，并分析TEM8的诊断价值。
选取2013年3月至2016年2月在扎兰屯中蒙医院和锦州医科大学附属第一医院确诊并治疗的204例肺癌患者作为研究组，选取203例健康受试者作为对照组。采用qRT-PCR技术检测TEM8表达。结合临床资料，分析TEM8对肺癌的诊断价值及与临床特征的相关性。比较TEM8表达高低患者的3年生存曲线。
研究组的表达明显高于对照组（P<0.05）。当截断值为1.125时，TEM8诊断肺癌的灵敏度、特异度和曲线下面积（AUC）分别为50.00%、98.00%和0.726。TEM8表达在吸烟、淋巴转移、TNM分期、分化程度和胸膜侵犯分级方面也存在差异（P<0.050）。生存组纳入132例患者，死亡组纳入72例患者。TEM8对预后的影响在两组间存在差异（P<0.001）。
研究组中TEM8呈高表达。TEM8具有良好的诊断效能，有望成为肺癌早期临床诊断和预后评估的优良指标。
