Oshika Tetsuro, Sasaki Noriyuki
Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Alcon Japan Ltd., Tokyo, Japan.
J Ophthalmol. 2021 Mar 31;2021:5548493. doi: 10.1155/2021/5548493. eCollection 2021.
To evaluate delivery performance of an automated preloaded intraocular lens (IOL) injector systems (AutonoMe) in the porcine eyes.
In the freshly excised porcine eyes, lens removal and IOL implantation were performed. There were 4 groups (10 eyes per group) with different incision site and size: 2.2-mm and 2.4-mm corneal incisions and 2.2-mm and 2.4-mm sclerocorneal incisions. Delivery performance and wound enlargement of AutonoMe were analyzed and compared with those of iTec and iSert from a previous study.
There were a few minor troubles associated with AutonoMe, such as overriding plunger within cartridge and trapped trailing haptic during IOL insertion, but the incidence was low. Other interactions were not observed, such as IOL adherence to plunger, sudden ejection of IOL, intrawound lens manipulation, IOL behavior, and gross damage to IOL. AutonoMe caused significantly less wound enlargement for both corneal and sclerocorneal incisions than other injector devices. Wound enlargement by using AutonoMe was significantly smaller with 2.4-mm corneal incision than with 2.2-mm corneal incision, but the final incision size was still smaller with 2.2-mm corneal incision. For sclerocorneal incisions, the amount of wound stretch was not different between 2.2 and 2.4 mm incisions.
The wound enlargement caused by the automated preloaded insertion system, AutonoMe, was smaller than that of other preloaded injectors for both corneal and sclerocorneal incisions. There were a few minor technical events during IOL insertion, but the overall incidence was low.
评估自动预装人工晶状体（IOL）注射器系统（AutonoMe）在猪眼中的植入性能。
在新鲜摘除的猪眼中进行晶状体摘除和IOL植入。有4组（每组10只眼），切口部位和大小不同：2.2毫米和2.4毫米角膜切口以及2.2毫米和2.4毫米角巩膜切口。分析AutonoMe的植入性能和伤口扩大情况，并与先前研究中的iTec和iSert进行比较。
AutonoMe存在一些小问题，如药筒内推杆 overriding（原文此处表述有误，推测可能是“overriding the plunger within cartridge”，即推杆在药筒内出现异常）以及IOL植入过程中后襻被困，但发生率较低。未观察到其他相互作用，如IOL粘附于推杆、IOL突然弹出、伤口内晶状体操作、IOL行为以及IOL严重损伤。与其他注射器装置相比，AutonoMe在角膜和角巩膜切口中导致的伤口扩大明显更小。使用AutonoMe时，2.4毫米角膜切口的伤口扩大明显小于2.2毫米角膜切口，但2.2毫米角膜切口的最终切口尺寸仍然更小。对于角巩膜切口，2.2毫米和2.4毫米切口的伤口拉伸量没有差异。
自动预装插入系统AutonoMe在角膜和角巩膜切口中引起的伤口扩大均小于其他预装注射器。IOL植入过程中存在一些小的技术问题，但总体发生率较低。
