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磁共振引导下的直肠癌放疗：器官保留的当前观点

MR-Guided Radiotherapy for Rectal Cancer: Current Perspective on Organ Preservation.

作者信息

Boldrini Luca, Intven Martijn, Bassetti Michael, Valentini Vincenzo, Gani Cihan

机构信息

Unità Operativa Complessa Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Roma, Italy.

Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy.

出版信息

Front Oncol. 2021 Mar 30;11:619852. doi: 10.3389/fonc.2021.619852. eCollection 2021.

DOI:10.3389/fonc.2021.619852
PMID:33859937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8042309/
Abstract

Online MRI-guided radiotherapy (MRgRT) is one of the most recent technological advances in radiotherapy. MRgRT permits the visualization of tumorous and healthy tissue while the patient is on the treatment table and online daily plan adaptations following the observed anatomical changes. In the context of rectal cancer, online MRgRT is a very promising modality due to the pronounced geographical variability of tumor tissues and the surrounding healthy tissues. This current paper will discuss the possible applications of online MRgRT, in particular, in terms of radiotherapy dose escalation and response prediction in organ preservation approaches for rectal cancer.

摘要

在线磁共振成像引导放疗（MRgRT）是放射治疗领域最新的技术进展之一。MRgRT能够在患者位于治疗台上时实现肿瘤组织和健康组织的可视化，并根据观察到的解剖学变化进行每日在线计划调整。在直肠癌的治疗中，由于肿瘤组织和周围健康组织存在显著的地理变异性，在线MRgRT是一种非常有前景的治疗方式。本文将讨论在线MRgRT的可能应用，特别是在直肠癌器官保留治疗方法中的放疗剂量递增和反应预测方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b01/8042309/c10fec8e17b4/fonc-11-619852-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b01/8042309/c10fec8e17b4/fonc-11-619852-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b01/8042309/c10fec8e17b4/fonc-11-619852-g0001.jpg

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本文引用的文献

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Quantitative magnetic resonance imaging on hybrid magnetic resonance linear accelerators: Perspective on technical and clinical validation.混合磁共振直线加速器上的定量磁共振成像：技术与临床验证的视角
Phys Imaging Radiat Oncol. 2020 Oct 17;16:69-73. doi: 10.1016/j.phro.2020.09.007. eCollection 2020 Oct.
2
1.5 T MR-linac planning study to compare two different strategies of rectal boost irradiation.1.5T磁共振直线加速器计划研究以比较两种不同的直肠后装放疗策略。
Clin Transl Radiat Oncol. 2020 Dec 3;26:86-91. doi: 10.1016/j.ctro.2020.11.016. eCollection 2021 Jan.
3
Online adaptive MR-guided radiotherapy for rectal cancer; feasibility of the workflow on a 1.5T MR-linac: clinical implementation and initial experience.
基于磁共振直线加速器的胃肠道癌放射治疗：一项叙述性综述
J Gastrointest Oncol. 2024 Aug 31;15(4):1893-1907. doi: 10.21037/jgo-22-961. Epub 2023 Sep 1.
4
Dose tracking assessment for magnetic resonance guided adaptive radiotherapy of rectal cancers.磁共振引导自适应放疗直肠癌的剂量跟踪评估。
Radiat Oncol. 2024 Sep 2;19(1):114. doi: 10.1186/s13014-024-02508-4.
5
Neoadjuvant treatment of rectal cancer: Where we are and where we are going.直肠癌的新辅助治疗：我们所处的位置与前进的方向
World J Clin Oncol. 2024 Jul 24;15(7):790-795. doi: 10.5306/wjco.v15.i7.790.
6
Potential dosimetric error in the adaptive workflow of a 1.5 T MR-Linac from patient movement relative to immobilisation systems.1.5TMR-Linac 自适应工作流程中因患者相对于固定系统的移动而导致的潜在剂量学误差。
Phys Eng Sci Med. 2024 Mar;47(1):351-359. doi: 10.1007/s13246-023-01369-7. Epub 2024 Jan 16.
7
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