P53调节细胞氧化还原状态、铁死亡和代谢。
P53 regulates cellular redox state, ferroptosis and metabolism.
作者信息
Leu Julia I-Ju, Murphy Maureen E, George Donna L
机构信息
Department of Genetics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
出版信息
Mol Cell Oncol. 2021 Feb 8;8(2):1877076. doi: 10.1080/23723556.2021.1877076. eCollection 2021.
Abstract
The tumor protein (, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sensitive proteins, thereby modifying metabolic processes and response to ferroptosis.
摘要
肿瘤蛋白（即p53）在代谢调节和铁死亡敏感性方面具有复杂且有时看似矛盾的作用。我们发现p53的作用会影响氧化还原状态，这会触发氧化还原敏感蛋白的变化，从而改变代谢过程和对铁死亡的反应。
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