Rad5的结构为深入了解其在复制应激耐受性中的作用提供了线索。
Structure of Rad5 provides insights into its role in tolerance to replication stress.
作者信息
Shen Miaomiao, Dhingra Nalini, Wang Quan, Gong Xiaoxin, Xu Xin, Niu Hengyao, Zhao Xiaolan, Xiang Song
机构信息
Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, P. R. China.
Molecular Biology Department, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
出版信息
Mol Cell Oncol. 2021 Mar 4;8(2):1889348. doi: 10.1080/23723556.2021.1889348. eCollection 2021.
Abstract
The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer. How their multiple activities coordinate has been unclear. Our recent study on Rad5 shed light on this question.
摘要
Rad5蛋白家族是关键的基因组维持因子，人类中的解旋酶样转录因子（HLTF）和SNF2组蛋白连接PHD环解旋酶（SHRPH）与多种癌症有关。它们的多种活性如何协调一直不清楚。我们最近对Rad5的研究揭示了这个问题。
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