Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript.
Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript.
Trends Genet. 2018 Aug;34(8):574-577. doi: 10.1016/j.tig.2018.04.006. Epub 2018 May 26.
Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.
不仅螺旋酶样转录因子（HLTF）和 SNF2 组蛋白连接子 PHD 指形 RING 指形螺旋酶（SHPRH）像它们的酵母对应物 Rad5 一样，在复制后修复中被证明是重要的参与者，而且它们还参与多种生物功能，并与几种人类疾病有关。我们在这里提供了它们的功能、相关疾病和潜在治疗方法的最新观点。
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