CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences At the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, 230026, Anhui Province, China.
Drug Deliv Transl Res. 2021 Aug;11(4):1475-1497. doi: 10.1007/s13346-021-00977-8. Epub 2021 Apr 15.
Inflammation is the biological response of immune system to protect living organisms from injurious factors. However, excessive and uncontrolled inflammation is implicated in a variety of devastating chronic diseases including atherosclerosis, inflammatory bowel disease (IBD), and rheumatoid arthritis (RA). Improved understanding of inflammatory response has unveiled a rich assortment of anti-inflammatory therapeutics for the treatment and management of relevant chronic diseases. Notwithstanding these successes, clinical outcomes are variable among patients and serious adverse effects are often observed. Moreover, there exist some limitations for clinical anti-inflammatory therapeutics such as aqueous insolubility, low bioavailability, off-target effects, and poor accessibility to subcellular compartments. To address these challenges, the rational design of inflammation-specific drug delivery systems (DDSs) holds significant promise. Moreover, as compared to normal tissues, inflamed tissue-associated pathological milieu (e.g., oxidative stress, acidic pH, and overexpressed enzymes) provides vital biochemical stimuli for triggered delivery of anti-inflammatory agents in a spatiotemporally controlled manner. In this review, we summarize recent advances in the development of anti-inflammatory DDSs with built-in pathological inflammation-specific responsiveness for the treatment of chronic inflammatory diseases.
炎症是免疫系统对有害因素的生物保护反应。然而，过度和不受控制的炎症与多种破坏性慢性疾病有关，包括动脉粥样硬化、炎症性肠病 (IBD) 和类风湿性关节炎 (RA)。对炎症反应的深入了解为治疗和管理相关慢性疾病提供了丰富多样的抗炎治疗方法。尽管取得了这些成功，但患者的临床结果存在差异，并且经常观察到严重的不良反应。此外，临床抗炎治疗方法存在一些局限性，例如水溶性差、生物利用度低、脱靶效应以及对亚细胞区室的不可及性。为了解决这些挑战，炎症特异性药物递送系统 (DDS) 的合理设计具有重要意义。此外，与正常组织相比，与炎症组织相关的病理微环境（例如氧化应激、酸性 pH 值和过表达的酶）为抗炎药物的时空控制递供提供了重要的生化刺激。在这篇综述中，我们总结了具有内置病理炎症特异性响应性的抗炎 DDS 的最新进展，用于治疗慢性炎症性疾病。
