School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
Department of Biotechnology, National Institute of Pharmaceutical Education & Research (NIPER), Hajipur, 844102, India.
Adv Drug Deliv Rev. 2023 Dec;203:115119. doi: 10.1016/j.addr.2023.115119. Epub 2023 Oct 28.
Inflammation is prevalent and inevitable in daily life but can generally be accommodated by the immune systems. However, incapable self-healing and persistent inflammation can progress to chronic inflammation, leading to prevalent or fatal chronic diseases. This review comprehensively covers the topic of emerging drug delivery systems (DDSs) for the treatment of chronic inflammatory diseases (CIDs). First, we introduce the basic biology of the chronic inflammatory process and provide an overview of the main CIDs of the major organs. Next, up-to-date information on various DDSs and the associated strategies for ensuring targeted delivery and stimuli-responsiveness applied to CIDs are discussed extensively. The implementation of traditional routes of drug administration to maximize their therapeutic effects against CIDs is then summarized. Finally, perspectives on future DDSs against CIDs are presented.
炎症在日常生活中普遍存在且不可避免，但通常可以被免疫系统所适应。然而，无法自我修复和持续的炎症可能会进展为慢性炎症，导致普遍存在或致命的慢性疾病。本综述全面涵盖了新兴药物递送系统（DDS）治疗慢性炎症性疾病（CIDs）的相关内容。首先，我们介绍了慢性炎症过程的基本生物学特性，并对主要器官的主要 CIDs 进行了概述。接下来，我们详细讨论了各种 DDS 及其相关策略，这些策略旨在确保针对 CIDs 的靶向递送和刺激响应。然后总结了传统药物给药途径的实施情况，以最大限度地提高其针对 CIDs 的治疗效果。最后，我们对针对 CIDs 的未来 DDS 进行了展望。
