基促进的烷基三氟砜的二氟烯基化反应。
Base promoted gem-difluoroolefination of alkyl triflones.
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China.
出版信息
Chem Commun (Camb). 2021 May 14;57(39):4831-4834. doi: 10.1039/d1cc01132d. Epub 2021 Apr 16.
PMID:33861249
Abstract
A new synthesis of gem-difluoroalkenes from readily available alkyl triflones and difluorocarbene precursors such as TMSCFBr has been reported. The reaction, regardless of electronic effect, gives gem-difluoroalkenes in good to excellent yields. The mechanism may involve deprotonation of triflones, nucleophilic addition, and the elimination of SOCF.
摘要
一种从易得的烷基三氟酮和二氟卡宾前体（如 TMSCFBr）合成偕二氟烯烃的新方法已经被报道。该反应无论电子效应如何，都能以良好到优异的收率得到偕二氟烯烃。该反应机理可能涉及三氟酮的脱质子化、亲核加成和 SOCF 的消除。
Zotero 插件