Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
J Mater Chem B. 2021 May 5;9(17):3689-3695. doi: 10.1039/d1tb00273b.
Exogenous reactive oxygen species (ROS) generation is a promising antibacterial strategy. The short diffusion distance coupled with the transient existence of ROS restrict their precise release at inflammation sites, so it is imperative to regulate the reactive sites of ROS donors. In this work, we developed a glycomimetic-decorated fluorescent nanobiocide to mediate the release of ROS generated from CuInS/ZnS quantum dots. The introduction of glycomimetics innovatively improved the biocompatibility of the hydrophobic quantum dots, allowing pathogenic bacteria to be targeted. The functionalized CuInS/ZnS quantum dots allowed simultaneous fluorescent reporting and sterilization under 660 nm illumination. Moreover, the nanobiocide can serve as a cell-binding glue causing bacterial aggregation, disrupting bacterial adhesion to host cells and inhibiting biofilm formation. Collectively, this work indicated the far-reaching future of ROS-generating biomimetic design for multifunctional nanobiocides to combat bacterial infections.
外源性活性氧（ROS）的产生是一种很有前途的抗菌策略。ROS 具有较短的扩散距离和短暂的存在时间，这限制了它们在炎症部位的精确释放，因此，调节 ROS 供体的反应位点势在必行。在这项工作中，我们开发了一种糖模拟物修饰的荧光纳米杀菌剂，用于介导 CuInS/ZnS 量子点产生的 ROS 的释放。糖模拟物的引入创新性地提高了疏水性量子点的生物相容性，使致病菌成为靶向目标。功能化的 CuInS/ZnS 量子点允许在 660nm 光照下同时进行荧光报告和杀菌。此外，纳米杀菌剂可以作为一种细胞结合胶，引起细菌聚集，破坏细菌对宿主细胞的黏附，并抑制生物膜的形成。总的来说，这项工作表明，用于多功能纳米杀菌剂的产生 ROS 的仿生设计具有广阔的前景，可以用于对抗细菌感染。
