Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada.
Adv Nutr. 2021 Oct 1;12(5):1705-1722. doi: 10.1093/advances/nmab024.
The etiology of cancer type may vary significantly due to anatomy, embryology, and physiology of the cancer site. Although the association between potato consumption and colorectal cancer (CRC) was summarized in a 2018 meta-analysis of 5 cohort studies, to the best of our knowledge, no meta-analysis has evaluated potato consumption in relation to multiple cancer sites in adults. Medline/PubMed, ISI Web of Knowledge, Scopus, and the Cochrane Database of Systematic Reviews were searched for relevant publications through August 2020. We selected cohort or case-control studies conducted in adults that reported risk estimates (relative risk [RRs], HRs, and ORs) of potato intake for any cancer type. Random effects meta-analyses compared high and low intake categories. Twenty prospective cohort studies (total n = 785,348) including 19,882 incident cases, and 36 case-control studies (21,822 cases; 66,502 controls) were included. Among cohort studies, we did not find an association between high versus low intake of total potato (white and yellow) consumption and overall cancers: 1.04 (95% CI: 0.96, 1.11; tau2 = 0.005, n = 18). We found no relation between total potato consumption (high compared with low intake) and risk of CRC, pancreatic cancer, colon, gastric, breast, prostate, kidney, lung, or bladder cancer in cohort or case-control studies. We did not find an association between high versus low consumption of potato preparations (boiled/fried/mashed/roasted/baked) and risk of gastrointestinal-, sex-hormone-, or urinary-related cancers in cohort or case-control studies. Certainty of the evidence was low for total cancer, CRC, colon, rectal, renal, pancreatic, breast, prostate, and lung cancer and very low for gastric and bladder cancer. In conclusion, potato intake or potato preparations were not associated with multiple cancer sites when comparing high and low intake categories. This finding was consistent with the findings from the 2018 meta-analysis regarding potato intake and risk of CRC.
癌症类型的病因可能因癌症部位的解剖学、胚胎学和生理学而有很大差异。尽管在 2018 年对 5 项队列研究的荟萃分析中总结了食用土豆与结直肠癌（CRC）之间的关联，但据我们所知，尚无荟萃分析评估过成年人中土豆摄入与多种癌症部位的关系。通过 2020 年 8 月，我们在 Medline/PubMed、ISI Web of Knowledge、Scopus 和 Cochrane 系统评价数据库中搜索了相关文献。我们选择了在成年人中进行的队列或病例对照研究，这些研究报告了摄入任何癌症类型的土豆的风险估计值（相对风险 [RR]、HR 和 OR）。随机效应荟萃分析比较了高摄入量和低摄入量类别。纳入了 20 项前瞻性队列研究（总计 n=785348 人，包括 19882 例新发病例）和 36 项病例对照研究（21822 例病例；66502 例对照）。在队列研究中，我们没有发现高摄入量与低摄入量之间总土豆（白色和黄色）摄入量与总体癌症之间存在关联：1.04（95%CI：0.96，1.11；tau2=0.005，n=18）。我们没有发现总土豆摄入量（与低摄入量相比）与 CRC、胰腺癌、结肠、胃、乳腺、前列腺、肾、肺或膀胱癌风险之间存在关系。在队列或病例对照研究中，我们没有发现高摄入量与低摄入量之间的关系食用土豆制品（煮/炸/泥/烤/烤）与胃肠道、性激素或泌尿系统癌症的风险之间存在关系。对于总体癌症、CRC、结肠、直肠、肾脏、胰腺、乳腺、前列腺和肺癌以及胃癌和膀胱癌，证据的确定性为低，而非常低。总之，在比较高摄入量和低摄入量类别时，土豆摄入量或土豆制品与多个癌症部位无关。这一发现与 2018 年关于土豆摄入量与 CRC 风险的荟萃分析结果一致。
