Park Seyeon, Ahn Seunghyun, Shin Yujeong, Yang Yoonjung, Yeom Chang H
Department of Applied Chemistry, Dongduk Women's University, Seoul, South Korea.
Department of Food and Nutrition, Dongduk Women's University, Seoul, South Korea.
Front Physiol. 2018 Jun 19;9:762. doi: 10.3389/fphys.2018.00762. eCollection 2018.
There is an ongoing interest in cellular antioxidants and oxidants as well as cellular mechanisms underlying their effects. Several reports suggest that vitamin C (L-ascorbic acid) functions as a pro-oxidant with selective toxicity against specific types of tumor cells. In addition, reduced glutathione plays an emerging role in reducing oxidative stress due to xenobiotic toxins such as metals and oxidants associated with diseases such as cancer, cardiovascular disease, and stroke. High-dose intravenous vitamin C and intravenous glutathione have been used as complementary, alternative, and adjuvant medicines. Here, we review the molecular mechanisms underlying the regulation of oxidation/reduction systems, focusing on the altered metabolomics profile in cancer cells following treatment with pharmacological vitamin C. This review focuses on the role of vitamin C in energy metabolism in terms of adenosine triphosphate, cysteine, and reduced glutathione levels, affecting cancer cell death.
人们对细胞抗氧化剂和氧化剂及其作用的细胞机制一直保持着关注。有几份报告表明，维生素C（L-抗坏血酸）作为一种对特定类型肿瘤细胞具有选择性毒性的促氧化剂发挥作用。此外，还原型谷胱甘肽在减轻由金属等外源性毒素以及与癌症、心血管疾病和中风等疾病相关的氧化剂引起的氧化应激方面正发挥着越来越重要的作用。高剂量静脉注射维生素C和静脉注射谷胱甘肽已被用作补充、替代和辅助药物。在此，我们综述氧化/还原系统调节的分子机制，重点关注用药理剂量维生素C治疗后癌细胞中代谢组学特征的改变。本综述聚焦于维生素C在能量代谢方面的作用，涉及三磷酸腺苷、半胱氨酸和还原型谷胱甘肽水平，这些影响癌细胞死亡。
